Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Malignant lymphoma incidence and HIV-related lymphoma subtypes in the Western Cape of South Africa, 2002-2009

Malignant lymphoma incidence and HIV-related lymphoma subtypes in the Western Cape of South... Abayomi et al. Infectious Agents and Cancer 2010, 5(Suppl 1):A53 http://www.infectagentscancer.com/content/5/S1/A53 MEETING ABSTRACTS Open Access Malignant lymphoma incidence and HIV-related lymphoma subtypes in the Western Cape of South Africa, 2002-2009 1,3 1 1 1 1 1 E Akin Abayomi , Avril Sommers , Ravnit Grewal , Gerhard Sissolak , Fatima Bassa , Deborah Maartens , 1 1 2,3* Peter Jacobs , Cristina Stefan , Leona W Ayers th From 12 International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI) Bethesda, MD, USA. 26-27 April, 2010 Background from the HIV-negative cases. ML subtypes of HIV-nega- The incidence of malignant lymphomas (ML) in the tive (488) and HIV-positive (118) cases are shown in Western Cape, a province of South Africa (SA), with a Table 1. population of 5 million and an estimated HIV preva- lence of 15% (census report 2002) has not been pre- Conclusions viously documented. Highly active antiretroviral therapy ML cases increased from 2002 to 2009 including a dra- (HAART) was introduced into the public patient sector matic increase in HRL, currently at 29% of all cases. in 2004, with 28% estimated coverage by 2007 This changing pattern of subtypes in PLWH presents (UNAIDS/WHO 2008). People living with HIV (PLWH) new challenges to histopathology diagnosis as well as a have 60-200 times increased risk of developing HIV- clinically more therapeutically difficult patient popula- related lymphoma (HRL). Therefore, based on HIV pre- tion. Burkitt lymphoma, the most common HRL, is valence, HRL would be expected to increase but is among emerging subtypes, along with plasmablastic undocumented. lymphoma, not previously seen in this geographic region. We anticipate the continued rise in HRL cases Materials and methods as PLWH live longer with HAART. Emergence of more We reviewed all patients diagnosed with ML from the Tygerberg Academic Hospital catchments area in the Table 1 Percentages of ML subtypes by HIV status. Western Cape of SA for years 2002-2009. In this time- Subtype %HIV- %HIV+ frame 606 cases of ML were identified, of which 488 Burkitt lymphoma 35 were HIV-negative and 118 HIV-positive. ML were sub- Diffuse large B-cell lymphoma 44 33 typed according to WHO classification (2008) based on Plasmablastic lymphoma 16 cell or tissue morphology and molecular and immuno- Follicular lymphoma 12 phenotypic platforms. Hodgkin’s lymphoma 11 5 Small cell lymphoma 4 1 Results Mucosa-associated lymphoid tissue (MALT) 4 1 ML cases increased each year from 2002 to 2005 and Anaplastic large cell lymphoma 3 3 remain elevated in both the HIV-negative and HIV-posi- Marginal zone lymphoma 3 tive patients through 2009. HRL increased from 5% in Cutaneous T-cell lymphoma 3 2002 to 30% in 2009 with a profile of subtypes differing T-cell lymphoma 2 1 Primary effusion lymphoma and Castleman’s disease 2 * Correspondence: ayers.1@osu.edu Other 13 4 Department of Pathology, The Ohio State University, Columbus, OH, USA Total 100 100 Full list of author information is available at the end of the article © 2010 Ayers et al; licensee BioMed Central Ltd. Abayomi et al. Infectious Agents and Cancer 2010, 5(Suppl 1):A53 Page 2 of 2 http://www.infectagentscancer.com/content/5/S1/A53 aggressive lymphoma subtypes inevitably poses a major strategic health concern in the region. We participate in the Sub-Saharan Africa Lymphoma Consortium [http:// www.ssalc.org] to expand the understanding of HRL in this region of the world. Acknowledgements This article has been published as part of Infectious Agents and Cancer th Volume 5 Supplement 1, 2010: Proceedings of the 12 International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI).The full contents of the supplement are available online at http://www.biomedcentral.com/1750-9378/5?issue=S1. Author details Division of Haematology, Stellenbosch University, Cape Town, South Africa. Department of Pathology, The Ohio State University, Columbus, OH, USA. Sub-Saharan Africa Lymphoma Consortium. Published: 11 October 2010 doi:10.1186/1750-9378-5-S1-A53 Cite this article as: Abayomi et al.: Malignant lymphoma incidence and HIV-related lymphoma subtypes in the Western Cape of South Africa, 2002-2009. Infectious Agents and Cancer 2010 5(Suppl 1):A53. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color figure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Infectious Agents and Cancer Springer Journals

Malignant lymphoma incidence and HIV-related lymphoma subtypes in the Western Cape of South Africa, 2002-2009

Download PDF
2 pages

Loading next page...
 
/lp/springer-journals/malignant-lymphoma-incidence-and-hiv-related-lymphoma-subtypes-in-the-7J30N09kSn

References (1)

Publisher
Springer Journals
Copyright
Copyright © 2010 by Ayers et al; licensee BioMed Central Ltd.
Subject
Biomedicine; Cancer Research; Infectious Diseases; Oncology
eISSN
1750-9378
DOI
10.1186/1750-9378-5-S1-A53
Publisher site
See Article on Publisher Site

Abstract

Abayomi et al. Infectious Agents and Cancer 2010, 5(Suppl 1):A53 http://www.infectagentscancer.com/content/5/S1/A53 MEETING ABSTRACTS Open Access Malignant lymphoma incidence and HIV-related lymphoma subtypes in the Western Cape of South Africa, 2002-2009 1,3 1 1 1 1 1 E Akin Abayomi , Avril Sommers , Ravnit Grewal , Gerhard Sissolak , Fatima Bassa , Deborah Maartens , 1 1 2,3* Peter Jacobs , Cristina Stefan , Leona W Ayers th From 12 International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI) Bethesda, MD, USA. 26-27 April, 2010 Background from the HIV-negative cases. ML subtypes of HIV-nega- The incidence of malignant lymphomas (ML) in the tive (488) and HIV-positive (118) cases are shown in Western Cape, a province of South Africa (SA), with a Table 1. population of 5 million and an estimated HIV preva- lence of 15% (census report 2002) has not been pre- Conclusions viously documented. Highly active antiretroviral therapy ML cases increased from 2002 to 2009 including a dra- (HAART) was introduced into the public patient sector matic increase in HRL, currently at 29% of all cases. in 2004, with 28% estimated coverage by 2007 This changing pattern of subtypes in PLWH presents (UNAIDS/WHO 2008). People living with HIV (PLWH) new challenges to histopathology diagnosis as well as a have 60-200 times increased risk of developing HIV- clinically more therapeutically difficult patient popula- related lymphoma (HRL). Therefore, based on HIV pre- tion. Burkitt lymphoma, the most common HRL, is valence, HRL would be expected to increase but is among emerging subtypes, along with plasmablastic undocumented. lymphoma, not previously seen in this geographic region. We anticipate the continued rise in HRL cases Materials and methods as PLWH live longer with HAART. Emergence of more We reviewed all patients diagnosed with ML from the Tygerberg Academic Hospital catchments area in the Table 1 Percentages of ML subtypes by HIV status. Western Cape of SA for years 2002-2009. In this time- Subtype %HIV- %HIV+ frame 606 cases of ML were identified, of which 488 Burkitt lymphoma 35 were HIV-negative and 118 HIV-positive. ML were sub- Diffuse large B-cell lymphoma 44 33 typed according to WHO classification (2008) based on Plasmablastic lymphoma 16 cell or tissue morphology and molecular and immuno- Follicular lymphoma 12 phenotypic platforms. Hodgkin’s lymphoma 11 5 Small cell lymphoma 4 1 Results Mucosa-associated lymphoid tissue (MALT) 4 1 ML cases increased each year from 2002 to 2005 and Anaplastic large cell lymphoma 3 3 remain elevated in both the HIV-negative and HIV-posi- Marginal zone lymphoma 3 tive patients through 2009. HRL increased from 5% in Cutaneous T-cell lymphoma 3 2002 to 30% in 2009 with a profile of subtypes differing T-cell lymphoma 2 1 Primary effusion lymphoma and Castleman’s disease 2 * Correspondence: ayers.1@osu.edu Other 13 4 Department of Pathology, The Ohio State University, Columbus, OH, USA Total 100 100 Full list of author information is available at the end of the article © 2010 Ayers et al; licensee BioMed Central Ltd. Abayomi et al. Infectious Agents and Cancer 2010, 5(Suppl 1):A53 Page 2 of 2 http://www.infectagentscancer.com/content/5/S1/A53 aggressive lymphoma subtypes inevitably poses a major strategic health concern in the region. We participate in the Sub-Saharan Africa Lymphoma Consortium [http:// www.ssalc.org] to expand the understanding of HRL in this region of the world. Acknowledgements This article has been published as part of Infectious Agents and Cancer th Volume 5 Supplement 1, 2010: Proceedings of the 12 International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI).The full contents of the supplement are available online at http://www.biomedcentral.com/1750-9378/5?issue=S1. Author details Division of Haematology, Stellenbosch University, Cape Town, South Africa. Department of Pathology, The Ohio State University, Columbus, OH, USA. Sub-Saharan Africa Lymphoma Consortium. Published: 11 October 2010 doi:10.1186/1750-9378-5-S1-A53 Cite this article as: Abayomi et al.: Malignant lymphoma incidence and HIV-related lymphoma subtypes in the Western Cape of South Africa, 2002-2009. Infectious Agents and Cancer 2010 5(Suppl 1):A53. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color figure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit

Journal

Infectious Agents and Cancer – Springer Journals

Published: Oct 11, 2010

There are no references for this article.