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Maternal use of oral contraceptives and risk of hypospadias – a population-based case-control study

Maternal use of oral contraceptives and risk of hypospadias – a population-based case-control study The aim of this population-based case-control study was to examine the risk of isolated hypospadias in boys born to mothers who have used oral contraceptives in early pregnancy. The study was based on data from the Hungarian Case-Control Surveillance of Congenital Abnormalities from 1980 to 1996, and included 3,038 boys with hypospadias (cases), 24,799 boys without congenital abnormalities (CA-free controls), and 11,881 boys with abnormalities other than hypospadias. We used unconditional logistic regression to adjust for birth order, maternal age, maternal employment status, maternal diabetes, and pre-eclampsia. When comparing cases with CA-free controls the OR for maternal use of OC was 1.21 (95% CI: 0.67–2.17). When comparing cases with boys with other abnormalities, the OR for maternal use of OC was 0.83 (95% CI: 0.46–1.50). Our data showed that self-reported maternal use of oral contraceptives during pregnancy was not associated with an increased risk of hypospadias in the offspring. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Epidemiology Springer Journals

Maternal use of oral contraceptives and risk of hypospadias – a population-based case-control study

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References (33)

Publisher
Springer Journals
Copyright
Copyright © 2006 by Springer Science+Business Media B.V.
Subject
Medicine & Public Health; Epidemiology; Public Health; Infectious Diseases; Cardiology; Oncology
ISSN
0393-2990
eISSN
1573-7284
DOI
10.1007/s10654-006-9067-0
pmid
17077991
Publisher site
See Article on Publisher Site

Abstract

The aim of this population-based case-control study was to examine the risk of isolated hypospadias in boys born to mothers who have used oral contraceptives in early pregnancy. The study was based on data from the Hungarian Case-Control Surveillance of Congenital Abnormalities from 1980 to 1996, and included 3,038 boys with hypospadias (cases), 24,799 boys without congenital abnormalities (CA-free controls), and 11,881 boys with abnormalities other than hypospadias. We used unconditional logistic regression to adjust for birth order, maternal age, maternal employment status, maternal diabetes, and pre-eclampsia. When comparing cases with CA-free controls the OR for maternal use of OC was 1.21 (95% CI: 0.67–2.17). When comparing cases with boys with other abnormalities, the OR for maternal use of OC was 0.83 (95% CI: 0.46–1.50). Our data showed that self-reported maternal use of oral contraceptives during pregnancy was not associated with an increased risk of hypospadias in the offspring.

Journal

European Journal of EpidemiologySpringer Journals

Published: Nov 1, 2006

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