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Medial vestibular nucleus in the guinea-pig

Medial vestibular nucleus in the guinea-pig 221 84 84 2 2 M. Serafin C. de Waele A. Khateb P. P. Vidal M. Mühlethaler Département de Physiologie CMU 1 Rue Michel Servet CH-1211 Genève 4 Switzerland Laboratoire de Physiologie Neurosensorielle, CNRS 15 Rue de l'Ecole de Médecine F-75270 Paris Cedex 06 France Summary In the preceding paper, medial vestibular nuclei neurones (MVNn) were shown to belong to two main classes, A MVNn and B MVNn, depending on their membrane properties in brainstem slices. In the following study we attempted to confirm this segregation by studying some of the ionic conductances that these cells are endowed with. Type A MVNn demonstrated small high threshold calcium spikes that could be potentiated by barium, a 4-AP resistant A-like conductance and a calcium-dependant afterhyperpolarization. Type B MVNn, in contrast, had large high threshold calcium spikes and prolonged calcium-dependant plateau potentials. In addition, they had a calcium-dependant afterhyperpolarization as well as a subthreshold persistent sodium conductance. A subpopulation of B MVNn had also low threshold calcium spikes that gave them bursting properties. These data confirm the segregation of MVN neurones into two main classes and will be discussed with respect to the firing characteristics of vestibular neurones in vivo. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experimental Brain Research Springer Journals

Medial vestibular nucleus in the guinea-pig

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References (19)

Publisher
Springer Journals
Copyright
Copyright © 1991 by Springer-Verlag
Subject
Biomedicine; Neurosciences; Neurology
ISSN
0014-4819
eISSN
1432-1106
DOI
10.1007/BF00231465
Publisher site
See Article on Publisher Site

Abstract

221 84 84 2 2 M. Serafin C. de Waele A. Khateb P. P. Vidal M. Mühlethaler Département de Physiologie CMU 1 Rue Michel Servet CH-1211 Genève 4 Switzerland Laboratoire de Physiologie Neurosensorielle, CNRS 15 Rue de l'Ecole de Médecine F-75270 Paris Cedex 06 France Summary In the preceding paper, medial vestibular nuclei neurones (MVNn) were shown to belong to two main classes, A MVNn and B MVNn, depending on their membrane properties in brainstem slices. In the following study we attempted to confirm this segregation by studying some of the ionic conductances that these cells are endowed with. Type A MVNn demonstrated small high threshold calcium spikes that could be potentiated by barium, a 4-AP resistant A-like conductance and a calcium-dependant afterhyperpolarization. Type B MVNn, in contrast, had large high threshold calcium spikes and prolonged calcium-dependant plateau potentials. In addition, they had a calcium-dependant afterhyperpolarization as well as a subthreshold persistent sodium conductance. A subpopulation of B MVNn had also low threshold calcium spikes that gave them bursting properties. These data confirm the segregation of MVN neurones into two main classes and will be discussed with respect to the firing characteristics of vestibular neurones in vivo.

Journal

Experimental Brain ResearchSpringer Journals

Published: Apr 1, 1991

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