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Medial vestibular nucleus in the guinea-pig: NMDA-induced oscillations

Medial vestibular nucleus in the guinea-pig: NMDA-induced oscillations 221 88 88 1 1 M. Serafin A. Khateb C. de Waele P. P. Vidal M. Mühlethaler Département de Physiologie CMU 1 Rue Michel Servet CH-1211 Genève 4 Switzerland Laboratoire de Physiologie Neurosensorielle CNRS 15 rue de l'Ecole de Médecine F-75270 Paris Cedex 06 France Summary We have recently shown in vivo that N-Methyl-D-Aspartate (NMDA) receptors are present in the guinea-pig vestibular complex and demonstrated that they are involved in the regulation of the resting discharge of vestibular neurones. A parallel in vitro study has identified in the guinea-pig medial vestibular nuclei (MVN) two main neuronal cell types, A and B MVNn, differing by their intrinsic membrane properties. One subtype of B MVNn was further characterized by the presence of a low threshold calcium spike (LTS). The present study investigated in vitro the responses of these different cell types to NMDA. Both A and B MVNn were depolarized by NMDA, which also induced a decrease in membrane resistance and an increase in the spontaneous firing rate. These effects could be blocked by D-AP5, a specific antagonist of NMDA receptors. Following a 10–30 mV hyperpolarization, a long-lasting oscillatory behavior could be induced in presence of NMDA. These oscillations were however restricted to the subtype of B MVNn without LTS. The NMDA-induced oscillations were tetrodotoxine-resistant, but could be eliminated by D-AP5 or by replacing sodium with choline. Functional implications of this oscillatory behavior are discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experimental Brain Research Springer Journals

Medial vestibular nucleus in the guinea-pig: NMDA-induced oscillations

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References (36)

Publisher
Springer Journals
Copyright
Copyright © 1992 by Springer-Verlag
Subject
Biomedicine; Neurosciences; Neurology
ISSN
0014-4819
eISSN
1432-1106
DOI
10.1007/BF02259140
Publisher site
See Article on Publisher Site

Abstract

221 88 88 1 1 M. Serafin A. Khateb C. de Waele P. P. Vidal M. Mühlethaler Département de Physiologie CMU 1 Rue Michel Servet CH-1211 Genève 4 Switzerland Laboratoire de Physiologie Neurosensorielle CNRS 15 rue de l'Ecole de Médecine F-75270 Paris Cedex 06 France Summary We have recently shown in vivo that N-Methyl-D-Aspartate (NMDA) receptors are present in the guinea-pig vestibular complex and demonstrated that they are involved in the regulation of the resting discharge of vestibular neurones. A parallel in vitro study has identified in the guinea-pig medial vestibular nuclei (MVN) two main neuronal cell types, A and B MVNn, differing by their intrinsic membrane properties. One subtype of B MVNn was further characterized by the presence of a low threshold calcium spike (LTS). The present study investigated in vitro the responses of these different cell types to NMDA. Both A and B MVNn were depolarized by NMDA, which also induced a decrease in membrane resistance and an increase in the spontaneous firing rate. These effects could be blocked by D-AP5, a specific antagonist of NMDA receptors. Following a 10–30 mV hyperpolarization, a long-lasting oscillatory behavior could be induced in presence of NMDA. These oscillations were however restricted to the subtype of B MVNn without LTS. The NMDA-induced oscillations were tetrodotoxine-resistant, but could be eliminated by D-AP5 or by replacing sodium with choline. Functional implications of this oscillatory behavior are discussed.

Journal

Experimental Brain ResearchSpringer Journals

Published: Jan 1, 1992

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