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Medical Applications of Finite Mixture ModelsAnalysis of Gene Expression Data

Medical Applications of Finite Mixture Models: Analysis of Gene Expression Data Chapter 8 The analysis of gene expression data is a rapidly growing field of medical research. There is a large and increasing body of statistical literature on the analysis of mi- croarray data. See, for example, the books by Parmigiani (2003), Simon et al. (2003), McLachlan et al. (2004), and Gentleman et al. (2005). Each human con- sists of a vast number of cells. With only a few exceptions, every cell of the body contains a full set of chromosomes contained in the nucleus. The human genome consists of 23 pairs of chromosomes which are the blueprint for all cellular activi- ties. One pair of chromosomes is inherited from the father, the other one from the mother. Each chromosome consists of a chain of intertwined DNA, the double he- lix. Only small portions of DNA contain information for protein construction. These are called genes. “Gene expression” is the term used to describe the transcription of the information contained within the DNA into messenger RNA (mRNA), which is translated into proteins after a mRNA processing step. These perform most of the critical functions of cells. Thus, each gene specifies the composition and structure of proteins via mRNA. This gene expression http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Medical Applications of Finite Mixture ModelsAnalysis of Gene Expression Data

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Publisher
Springer Berlin Heidelberg
Copyright
© Springer-Verlag Berlin Heidelberg 2009
ISBN
978-3-540-68650-7
Pages
1 –17
DOI
10.1007/978-3-540-68651-4_8
Publisher site
See Chapter on Publisher Site

Abstract

Chapter 8 The analysis of gene expression data is a rapidly growing field of medical research. There is a large and increasing body of statistical literature on the analysis of mi- croarray data. See, for example, the books by Parmigiani (2003), Simon et al. (2003), McLachlan et al. (2004), and Gentleman et al. (2005). Each human con- sists of a vast number of cells. With only a few exceptions, every cell of the body contains a full set of chromosomes contained in the nucleus. The human genome consists of 23 pairs of chromosomes which are the blueprint for all cellular activi- ties. One pair of chromosomes is inherited from the father, the other one from the mother. Each chromosome consists of a chain of intertwined DNA, the double he- lix. Only small portions of DNA contain information for protein construction. These are called genes. “Gene expression” is the term used to describe the transcription of the information contained within the DNA into messenger RNA (mRNA), which is translated into proteins after a mRNA processing step. These perform most of the critical functions of cells. Thus, each gene specifies the composition and structure of proteins via mRNA. This gene expression

Published: Dec 8, 2008

Keywords: Acute Myeloid Leukemia; Mixture Model; Gene Expression Data; Differential Gene Expression; Finite Mixture Model

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