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Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points of agreement

Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points... Molecular Psychiatry (2008) 13, 466–469 & 2008 Nature Publishing Group All rights reserved 1359-4184/08 $30.00 www.nature.com/mp LETTERS TO THE EDITOR Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points of agreement Molecular Psychiatry (2008) 13, 466–467; imputation data set of the WTCCC. The number of doi:10.1038/mp.2008.16 randomly sampled SNP sets in which the best five P-values were less than or equal to the best five P-values in the observed SNP set was tallied. About Two genome-wide association studies (GWAS) of 700 random sets of SNPs met this criterion, for an bipolar disorder have been published to date, one in 1 2 empirical P=7 10 . Because this procedure tests this journal and one in Nature. Cursory considera- only one hypothesis, we can confidently reject the tion of the top findings in the two studies does null hypothesis of no common genetic signals not show obvious overlap; some may even have between the two studies. concluded that there is no agreement. Yet, simula- Next we examined the 27 SNPs that had been tions show that true positive findings have only a individually genotyped in both Baum et al. samples 26% chance of falling into the top 1000 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Psychiatry Springer Journals

Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points of agreement

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References (15)

Publisher
Springer Journals
Copyright
Copyright © 2008 by Nature Publishing Group
Subject
Medicine & Public Health; Medicine/Public Health, general; Psychiatry; Neurosciences; Behavioral Sciences; Pharmacotherapy; Biological Psychology
ISSN
1359-4184
eISSN
1476-5578
DOI
10.1038/mp.2008.16
Publisher site
See Article on Publisher Site

Abstract

Molecular Psychiatry (2008) 13, 466–469 & 2008 Nature Publishing Group All rights reserved 1359-4184/08 $30.00 www.nature.com/mp LETTERS TO THE EDITOR Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points of agreement Molecular Psychiatry (2008) 13, 466–467; imputation data set of the WTCCC. The number of doi:10.1038/mp.2008.16 randomly sampled SNP sets in which the best five P-values were less than or equal to the best five P-values in the observed SNP set was tallied. About Two genome-wide association studies (GWAS) of 700 random sets of SNPs met this criterion, for an bipolar disorder have been published to date, one in 1 2 empirical P=7 10 . Because this procedure tests this journal and one in Nature. Cursory considera- only one hypothesis, we can confidently reject the tion of the top findings in the two studies does null hypothesis of no common genetic signals not show obvious overlap; some may even have between the two studies. concluded that there is no agreement. Yet, simula- Next we examined the 27 SNPs that had been tions show that true positive findings have only a individually genotyped in both Baum et al. samples 26% chance of falling into the top 1000

Journal

Molecular PsychiatrySpringer Journals

Published: Apr 18, 2008

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