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Modeling of Biological MaterialsBiochemical and Biomechanical Aspects of Blood Flow

Modeling of Biological Materials: Biochemical and Biomechanical Aspects of Blood Flow [The blood vital functions are adaptative and strongly regulated. The various processes associated with the flowing blood involve multiple space and time scales. Biochemical and biomechanical aspects of the human blood circulation are indeed strongly coupled. The functioning of the heart, the transduction of mechanical stresses applied by the flowing blood on the endothelial and smooth muscle cells of the vessel wall, gives examples of the links between biochemistry and biomechanics in the physiology of the cardiovascular system and its regulation. The remodeling of the vessel of any site of the vasculature (blood vessels, heart) when the blood pressure increases, the angiogenesis, which occurs in tumors or which shunts a stenosed artery, illustrates pathophysiological processes. Moreover, focal wall pathologies, with the dysfunction of its biochemical machinery, such as lumen dilations (aneurisms) or narrowings (stenoses), are stress-dependent. This review is aimed at emphasizing the multidisciplinary aspects of investigations of multiple aspects of the blood flow] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Modeling of Biological MaterialsBiochemical and Biomechanical Aspects of Blood Flow

Part of the Modeling and Simulation in Science, Engineering and Technology Book Series
Editors: Mollica, Francesco; Preziosi, Luigi; Rajagopal, K. R.
Thiriet, M.
Modeling of Biological Materials — Jan 1, 2007
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68 pages

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Publisher
Birkhäuser Boston
Copyright
© Birkhäuser Boston 2007
ISBN
978-0-8176-4410-9
Pages
33 –100
DOI
10.1007/978-0-8176-4411-6_2
Publisher site
See Chapter on Publisher Site

Abstract

[The blood vital functions are adaptative and strongly regulated. The various processes associated with the flowing blood involve multiple space and time scales. Biochemical and biomechanical aspects of the human blood circulation are indeed strongly coupled. The functioning of the heart, the transduction of mechanical stresses applied by the flowing blood on the endothelial and smooth muscle cells of the vessel wall, gives examples of the links between biochemistry and biomechanics in the physiology of the cardiovascular system and its regulation. The remodeling of the vessel of any site of the vasculature (blood vessels, heart) when the blood pressure increases, the angiogenesis, which occurs in tumors or which shunts a stenosed artery, illustrates pathophysiological processes. Moreover, focal wall pathologies, with the dysfunction of its biochemical machinery, such as lumen dilations (aneurisms) or narrowings (stenoses), are stress-dependent. This review is aimed at emphasizing the multidisciplinary aspects of investigations of multiple aspects of the blood flow]

Published: Jan 1, 2007

Keywords: Nitric Oxide; Wall Shear Stress; Focal Adhesion Kinase; Biological Material; Atrial Natriuretic Peptide

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