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Modeling of Biological MaterialsRegulation of Hemostatic System Function by Biochemical and Mechanical Factors

Modeling of Biological Materials: Regulation of Hemostatic System Function by Biochemical and... [The mammalian hemostatic system has evolved to accomplish the task of sealing defects in the cardiovascular system. Hemostasis occurs in and around a disruption in a vascular conduit through which blood normally flows, and is characterized by the localized formation of thrombus. Consequently, the process of hemostasis is influenced by: (1) the biochemical properties of the cellular and soluble components of the hemostatic system, counterregulatory networks, and the vascular conduit; (2) the local hemodynamic conditions, which regulate the influx and efflux of substrates, cofactors, and catalysts, and which also impose loads on the forming clot; and (3) the local mechanical properties of the vasculature. We review the components of the hemostatic and negative regulatory systems and their biochemical functions, and the roles that local hemodynamics play in the regulation of hemostasis] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Modeling of Biological MaterialsRegulation of Hemostatic System Function by Biochemical and Mechanical Factors

Part of the Modeling and Simulation in Science, Engineering and Technology Book Series
Editors: Mollica, Francesco; Preziosi, Luigi; Rajagopal, K. R.
Rajagopal, K.; Lawson, J.
Modeling of Biological Materials — Jan 1, 2007
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32 pages

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Publisher
Birkhäuser Boston
Copyright
© Birkhäuser Boston 2007
ISBN
978-0-8176-4410-9
Pages
179 –210
DOI
10.1007/978-0-8176-4411-6_5
Publisher site
See Chapter on Publisher Site

Abstract

[The mammalian hemostatic system has evolved to accomplish the task of sealing defects in the cardiovascular system. Hemostasis occurs in and around a disruption in a vascular conduit through which blood normally flows, and is characterized by the localized formation of thrombus. Consequently, the process of hemostasis is influenced by: (1) the biochemical properties of the cellular and soluble components of the hemostatic system, counterregulatory networks, and the vascular conduit; (2) the local hemodynamic conditions, which regulate the influx and efflux of substrates, cofactors, and catalysts, and which also impose loads on the forming clot; and (3) the local mechanical properties of the vasculature. We review the components of the hemostatic and negative regulatory systems and their biochemical functions, and the roles that local hemodynamics play in the regulation of hemostasis]

Published: Jan 1, 2007

Keywords: Wall Shear Stress; Tissue Factor; Thrombus Formation; Clot Formation; Mechanical Factor

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