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Molecular Mechanism for the Interaction of Phospholipid with Cholesterol

Molecular Mechanism for the Interaction of Phospholipid with Cholesterol Abstract PREVIOUS models1–3 for the interaction of phospholipid with cholesterol have been based on the idea of highly specific one-to-one complexes of these molecules. But on the basis of our interpretation of recent nuclear magnetic resonance (NMR)4, electron spin resonance (ESR)5, calorimetric6, and X-ray7 data we propose a model in which steric interaction of the phospholipid hydrocarbon chains with the cholesterol molecule is the dominant feature. The validity of the model does not depend on a stoichiometric ratio, such as one-to-one, although it is consistent with such a ratio. The shape of the cholesterol molecule is such that variations in the length and degree of saturation of the phospholipid hydrocarbon chains can be readily accommodated within a stable bilayer structure. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature New Biology Springer Journals

Molecular Mechanism for the Interaction of Phospholipid with Cholesterol

Nature New Biology , Volume 237 (71): 3 – May 1, 1972

Molecular Mechanism for the Interaction of Phospholipid with Cholesterol

Nature New Biology , Volume 237 (71): 3 – May 1, 1972

Abstract

Abstract PREVIOUS models1–3 for the interaction of phospholipid with cholesterol have been based on the idea of highly specific one-to-one complexes of these molecules. But on the basis of our interpretation of recent nuclear magnetic resonance (NMR)4, electron spin resonance (ESR)5, calorimetric6, and X-ray7 data we propose a model in which steric interaction of the phospholipid hydrocarbon chains with the cholesterol molecule is the dominant feature. The validity of the model does not depend on a stoichiometric ratio, such as one-to-one, although it is consistent with such a ratio. The shape of the cholesterol molecule is such that variations in the length and degree of saturation of the phospholipid hydrocarbon chains can be readily accommodated within a stable bilayer structure.

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References (14)

Publisher
Springer Journals
Copyright
1972 Nature Publishing Group
ISSN
2058-1092
eISSN
2058-1092
DOI
10.1038/newbio237042a0
Publisher site
See Article on Publisher Site

Abstract

Abstract PREVIOUS models1–3 for the interaction of phospholipid with cholesterol have been based on the idea of highly specific one-to-one complexes of these molecules. But on the basis of our interpretation of recent nuclear magnetic resonance (NMR)4, electron spin resonance (ESR)5, calorimetric6, and X-ray7 data we propose a model in which steric interaction of the phospholipid hydrocarbon chains with the cholesterol molecule is the dominant feature. The validity of the model does not depend on a stoichiometric ratio, such as one-to-one, although it is consistent with such a ratio. The shape of the cholesterol molecule is such that variations in the length and degree of saturation of the phospholipid hydrocarbon chains can be readily accommodated within a stable bilayer structure.

Journal

Nature New BiologySpringer Journals

Published: May 1, 1972

Keywords: life sciences, general

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