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- Publisher
- Springer Journals
- Copyright
- Copyright © 2005 by Springer
- Subject
- Biomedicine; Biomedicine general; Pharmacology/Toxicology; Human Physiology; Neurosciences; Cancer Research
- ISSN
- 1573-9538
- eISSN
- 1573-9546
- DOI
- 10.1007/s11302-005-8077-9
- pmid
- 18404522
- Publisher site
- See Article on Publisher Site
Abstract
We have previously reported that ATPγS, a slowly hydrolyzed analog of ATP, inhibits the activation of human CD4+ T lymphocytes by anti-CD3 and anti-CD28 mAb. In this report we have partially characterized the signaling mechanisms involved in this immunosuppressive effect. ATPγS had no inhibitory effect on CD4+ T-cell activation induced by PMA and anti-CD28, indicating that it acts proximally to the TCR. It had no effect on the calcium rise induced by CD3/CD28 stimulation, but inhibited the phosphorylation of three kinases, ERK2, p38 MAPK and PKB, that play a key role in the activation of T cells. The receptor involved in these actions remains unidentified.
Journal
Purinergic Signalling – Springer Journals
Published: Dec 3, 2005