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Mothering style and methylation

Mothering style and methylation Frequent licking and grooming by rat mothers increases the number of hippocampal glucocorticoid receptors in their pups, leading to tighter regulation of stress hormone levels. A study in this issue shows that this treatment alters DNA methylation of the glucocorticoid receptor gene and acetylation of histones early in life, providing a mechanism for these permanent changes in stress responses. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Neuroscience Springer Journals

Mothering style and methylation

Nature Neuroscience , Volume 7 (8) – Aug 1, 2004

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References (21)

Publisher
Springer Journals
Copyright
Copyright © 2004 by Nature Publishing Group
Subject
Biomedicine; Biomedicine, general; Neurosciences; Behavioral Sciences; Biological Techniques; Neurobiology; Animal Genetics and Genomics
ISSN
1097-6256
eISSN
1546-1726
DOI
10.1038/nn0804-791
Publisher site
See Article on Publisher Site

Abstract

Frequent licking and grooming by rat mothers increases the number of hippocampal glucocorticoid receptors in their pups, leading to tighter regulation of stress hormone levels. A study in this issue shows that this treatment alters DNA methylation of the glucocorticoid receptor gene and acetylation of histones early in life, providing a mechanism for these permanent changes in stress responses.

Journal

Nature NeuroscienceSpringer Journals

Published: Aug 1, 2004

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