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Nanofibers for the Immunoregulation in Biomedical Applications

Nanofibers for the Immunoregulation in Biomedical Applications Despite great efforts and achievement of nanomaterials in immune-associated diseases, the selection of appropriate nanomaterials and preparation technology remain some challenges and vast room for improvement. Immunotherapy has received tremendous attention throughout the medical process due to its clinical successes with the pathways of immunoactivation or immunosuppression. Recently, fibrous nanomaterials have facilitated advances in tissue repair and cancer treatments owing to the superiority of multi-channel structure, biocompatibility, tunable size and controlled surface modification. The immunoactivation-based nanofibers can potentially deliver functional agents to lesions and further actively promote immunologic intervention. On the contrary, the immunosuppression-based nanofibers prevent the immune system from overreacting through the blockage of critical pathways in vivo. This review summarizes the current application of nanofiber materials in diverse diseases, including cancer therapy, tissue regeneration (cartilage/bone, skin, tendon, nerves), myocardial infarction, psoriasis and organ defects. Some common fabrication technologies of biomedical nanofibers are also introduced. Meanwhile, the existing technical barriers and perspectives are rationally discussed, providing a constructive inspiration for the follow-up basic research and clinical transformation of nanofibers in the vibrant biomedical fields.Graphical AbstractSchematic illustration of nanofibers applied in immunoregulation-based therapy. A variety of diseases can be treated via regulating immune microenvironment including tendon regeneration, bone/cartilage repair, nerve regeneration, skin regeneration and cancer therapy. Therefore, multifunctional nanofibers can provide opportunities for future construction of efficient immune therapy for cancer immunotherapy, tissue regeneration[graphic not available: see fulltext] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Advanced Fiber Materials Springer Journals

Nanofibers for the Immunoregulation in Biomedical Applications

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Springer Journals
Copyright
Copyright © Donghua University, Shanghai, China 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
ISSN
2524-7921
eISSN
2524-793X
DOI
10.1007/s42765-022-00191-2
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Abstract

Despite great efforts and achievement of nanomaterials in immune-associated diseases, the selection of appropriate nanomaterials and preparation technology remain some challenges and vast room for improvement. Immunotherapy has received tremendous attention throughout the medical process due to its clinical successes with the pathways of immunoactivation or immunosuppression. Recently, fibrous nanomaterials have facilitated advances in tissue repair and cancer treatments owing to the superiority of multi-channel structure, biocompatibility, tunable size and controlled surface modification. The immunoactivation-based nanofibers can potentially deliver functional agents to lesions and further actively promote immunologic intervention. On the contrary, the immunosuppression-based nanofibers prevent the immune system from overreacting through the blockage of critical pathways in vivo. This review summarizes the current application of nanofiber materials in diverse diseases, including cancer therapy, tissue regeneration (cartilage/bone, skin, tendon, nerves), myocardial infarction, psoriasis and organ defects. Some common fabrication technologies of biomedical nanofibers are also introduced. Meanwhile, the existing technical barriers and perspectives are rationally discussed, providing a constructive inspiration for the follow-up basic research and clinical transformation of nanofibers in the vibrant biomedical fields.Graphical AbstractSchematic illustration of nanofibers applied in immunoregulation-based therapy. A variety of diseases can be treated via regulating immune microenvironment including tendon regeneration, bone/cartilage repair, nerve regeneration, skin regeneration and cancer therapy. Therefore, multifunctional nanofibers can provide opportunities for future construction of efficient immune therapy for cancer immunotherapy, tissue regeneration[graphic not available: see fulltext]

Journal

Advanced Fiber Materials – Springer Journals

Published: Dec 1, 2022

Keywords: Nanofibers; Immunoregulation; Tissue repair; Cancer therapy

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  • Oriented nanofibrous P(MMD-co-LA)/Deferoxamine nerve scaffold facilitates peripheral nerve regeneration by regulating macrophage phenotype and revascularization
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