Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Nivolumab-induced small bowel obstruction and perforation: a rare but life-threatening side effect of immunotherapy

Nivolumab-induced small bowel obstruction and perforation: a rare but life-threatening side... We present a case of a 58-year-old female with anti-PD-1 immunotherapy-related small bowel perforation. The patient was on long-term therapy with nivolumab for metastatic non-small cell lung cancer. She presented to the emergency department with acute abdominal pain, in which the CT revealed a short segment of dilated distal ileum proximal to a very short segment of bowel with mural thickening and a perforation near the transition point. The patient underwent subsequent laparotomy, which confirmed the CT findings and revealed a short-segment of friable and dilated loop of distal ileum proximal to a stricture and a small perforation at the transition point. Pathological analysis revealed mural thickening at the site of stricture without evidence of malignancy with focal necrosis and perforation at the transition point. Bowel perforation in the setting of anti-PD-1 immunotherapy is rare, but life-threatening complication, and should be considered in oncology patients on immunotherapy presenting with severe abdominal pain. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Emergency Radiology Springer Journals

Nivolumab-induced small bowel obstruction and perforation: a rare but life-threatening side effect of immunotherapy

Loading next page...
 
/lp/springer-journals/nivolumab-induced-small-bowel-obstruction-and-perforation-a-rare-but-SVmIo0M14V

References (13)

Publisher
Springer Journals
Copyright
Copyright © American Society of Emergency Radiology 2019
Subject
Medicine & Public Health; Imaging / Radiology; Emergency Medicine
ISSN
1070-3004
eISSN
1438-1435
DOI
10.1007/s10140-019-01731-x
Publisher site
See Article on Publisher Site

Abstract

We present a case of a 58-year-old female with anti-PD-1 immunotherapy-related small bowel perforation. The patient was on long-term therapy with nivolumab for metastatic non-small cell lung cancer. She presented to the emergency department with acute abdominal pain, in which the CT revealed a short segment of dilated distal ileum proximal to a very short segment of bowel with mural thickening and a perforation near the transition point. The patient underwent subsequent laparotomy, which confirmed the CT findings and revealed a short-segment of friable and dilated loop of distal ileum proximal to a stricture and a small perforation at the transition point. Pathological analysis revealed mural thickening at the site of stricture without evidence of malignancy with focal necrosis and perforation at the transition point. Bowel perforation in the setting of anti-PD-1 immunotherapy is rare, but life-threatening complication, and should be considered in oncology patients on immunotherapy presenting with severe abdominal pain.

Journal

Emergency RadiologySpringer Journals

Published: Feb 10, 2020

There are no references for this article.