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Optimal Impulsive Control for Cancer TherapyPharmacokinetic and Pharmacodynamical Models

Optimal Impulsive Control for Cancer Therapy: Pharmacokinetic and Pharmacodynamical Models [This chapter presents the Pharmacokinetic (PK) and Pharmacodynamical (PD) models. Concerning PK models, empirical and mechanistic models are explained, including their advantages and disadvantages. Compartmental models are described, including a discussion on their properties: positivity, mass conservation and stability. For PD models, such as for the PK models, empirical models and mechanistic models are referred as well. The mechanistic model described by the Hill equation is studied for different drugs and configurations.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Optimal Impulsive Control for Cancer TherapyPharmacokinetic and Pharmacodynamical Models

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Publisher
Springer International Publishing
Copyright
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2021
ISBN
978-3-030-50487-8
Pages
11 –18
DOI
10.1007/978-3-030-50488-5_2
Publisher site
See Chapter on Publisher Site

Abstract

[This chapter presents the Pharmacokinetic (PK) and Pharmacodynamical (PD) models. Concerning PK models, empirical and mechanistic models are explained, including their advantages and disadvantages. Compartmental models are described, including a discussion on their properties: positivity, mass conservation and stability. For PD models, such as for the PK models, empirical models and mechanistic models are referred as well. The mechanistic model described by the Hill equation is studied for different drugs and configurations.]

Published: Jun 20, 2020

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