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Gurinderdeep Singh (2017)Piperine: A Remarkable Marker with Intense Biological Activity
V. Parthasarathy, B. Chempakam, T. Zachariah (2008)Chemistry of Spices
V. Yadav, S. Chatterjee, M. Majeed, Vikas Kumar (2015)Preventive potentials of piperlongumine and a Piper longum extract against stress responses and pain
Journal of Traditional and Complementary Medicine, 6
S. Panthong, Y. Imai, Takeshi Matsuoka, Wakana Suzuki, Tatsuo Watanabe, Y. Terada, K. Kurohane, Kota Sekiguchi, Erina Ogawa, Yukina Endo, A. Itharat (2020)The role of Piper chaba Hunt. and its pure compound, piperine, on TRPV1 activation and adjuvant effect
BMC Complementary Medicine and Therapies, 20
Z. Stojanović-Radić, Milica Pejčić, M. Dimitrijević, A. Aleksić, Nanjangud Kumar, B. Salehi, William Cho, J. Sharifi‐Rad (2019)Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies
(1993)Compendium of Indian Medicinal plants CDRI Lucknow and New Delhi: Nisc
Heerasing Takooree, M. Aumeeruddy, Kannan Rengasamy, K. Venugopala, R. Jeewon, G. Zengin, M. Mahomoodally (2019)A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications
Critical Reviews in Food Science and Nutrition, 59
P. Pinsornsak, Puritat Kanokkangsadal, A. Itharat (2015)The Clinical Efficacy and Safety of the Sahastara Remedy versus Diclofenac in the Treatment of Osteoarthritis of the Knee: A Double-Blind, Randomized, and Controlled Trial
Evidence-based Complementary and Alternative Medicine : eCAM, 2015
Jiu-wang Yu, H. Yuan, L. Bao, Leng-ge Si (2020)Interaction between piperine and genes associated with sciatica and its mechanism based on molecular docking technology and network pharmacology
Molecular Diversity, 25
Shubham Atal, P. Phadnis, S. Vyas, Gopal Gudsurkar, Ritesh Churihar (2016)EVALUATION OF THE INTERACTION OF PIPERINE WITH ANTIDEPRESSANT SERTRALINE AND ANALGESIC PENTAZOCINE, USING DIFFERENT ROUTES OF ADMINISTRATION IN ALBINO MICE
Asian Journal of Pharmaceutical and Clinical Research, 9
D. Suresh, K. Srinivasan (2010)Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats.
The Indian journal of medical research, 131
J. Gertsch, M. Leonti, Stefan Raduner, I. Rácz, Jian-zhong Chen, X. Xie, K. Altmann, M. Karsak, A. Zimmer (2008)Beta-caryophyllene is a dietary cannabinoid
Proceedings of the National Academy of Sciences, 105
Kholkute Sd, Kekare Mb, Munshi (1979)Antifertility effects of the fruits of Piper longum in female rats.
Indian journal of experimental biology, 17 3
R. Costaa, J. Machadoa, C. Abreuc (2016)Evaluation of Analgesic Properties of Piper Nigrum Essential Oil: a Randomized, Double-blind, Placebo-controlled Study
Yuanbin Zhang, Xinfang Wang, Ling Ma, Lin Dong, Xinhui Zhang, Jing Chen, Xueyan Fu (2014)Anti-inflammatory, antinociceptive activity of an essential oil recipe consisting of the supercritical fluid CO2 extract of white pepper, long pepper, cinnamon, saffron and myrrh in vivo.
Journal of oleo science, 63 12
R.Costa, J. Machado, C.Abreu (2016)Evaluation of Analgesic Properties of Piper Nigrum Essential Oil: a Randomized, Double-blind, Placebo-controlled Study
Traditional Chinese Medicine, 2
G. Vedhanayaki, G. Shastri, A. Kuruvilla (2003)Analgesic activity of Piper longum Linn. root.
Indian journal of experimental biology, 41 6
Farhana Tasleem, Iqbal Azhar, Syed Ali, S. Perveen, Z. Mahmood (2014)Analgesic and anti-inflammatory activities of Piper nigrum L.
Asian Pacific journal of tropical medicine, 7S1
M. Chaudhury, R. Chandrasekaran, S. Mishra (2001)Embryotoxicity and teratogenicity studies of an ayurvedic contraceptive--pippaliyadi vati.
Journal of ethnopharmacology, 74 2
Z. Damanhouri, Aftab Ahmad (2014)A Review on Therapeutic Potential of Piper nigrum L. (Black Pepper): The King of Spices
Medicinal and Aromatic plants, 3
S. Jayakumar, S. Sathiskumar, N. Baskaran, R. Arumugam, V. Vanitha (2017)Ethno-veterinary practices in Southern India for captive Asian elephant ailments.
Journal of ethnopharmacology, 200
M. Alhumayyd, I. Bukhari, Abdul Mahesar, A. Gilani (2013)The analgesic and anticonvulsant effects of Piperine in mice
The FASEB Journal, 27
Siharat Chunlaratthanaphorn, N. Lertprasertsuke, U. Srisawat, Amornnat Thuppia, Anongnad Ngamjariyawat, Nadthaganya Suwanlikhid, K. Jaijoy (2007)Acute and subchronic toxicity study of the water extract from dried fruits of Piper nigrum L. in rats
Songklanakarin Journal of Science and Technology (SJST), 29
P. Piyachaturawat, T. Glinsukon, C. Toskulkao (1983)Acute and subacute toxicity of piperine in mice, rats and hamsters.
Toxicology letters, 16 3-4
Xiao-zhou Ying, Xiaowei Chen, Shao-wen Cheng, Yue Shen, Lei Peng, H. Xu (2013)Piperine inhibits IL-β induced expression of inflammatory mediators in human osteoarthritis chondrocyte.
International immunopharmacology, 17 2
S. Sudjarwo (2005)The Potency of Piperine as Antiinflammatory and Analgesic in Rats and Mice
Evan Sabinaa, A. Nasreen, M. Vedi, M. Rasool (2013)Analgesic, Antipyretic and Ulcerogenic Effects of Piperine: An Active Ingredient of Pepper
(1997)Analgesic effect of hydroalcoholic extract of Zingiber and Piper nigrum in mice by tail-flick test
R. Dogra, S. Khanna, Ravi Shanker (2004)Immunotoxicological effects of piperine in mice.
Toxicology, 196 3
D. Becker (2010)Pain management: Part 1: Managing acute and postoperative dental pain.
Anesthesia progress, 57 2
J. Bang, D. Oh, H. Choi, Bongjun Sur, Sung‐Jig Lim, Jung Kim, Hyung‐In Yang, M. Yoo, D. Hahm, K. Kim (2009)Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1β-stimulated fibroblast-like synoviocytes and in rat arthritis models
Arthritis Research & Therapy, 11
Pain is considered as an unpleasant distressing feeling in different parts of body in response to different stimuli. The use of opioids, narcotic and non-narcotic drugs is associated with adverse effects; therefore, research on natural analgesics has been the subjects of many investigations. Due to the traditional importance of Piper nigrum in management of pain, the subject of this article was to evaluate the potency of P. nigrum in pain. The electronic sources (PubMed, Science Direct, Wiley, Springer, etc.) were used to prepare the manuscript by the key words of “black pepper”, “Piper nigrum” and “pain”. The results of different animal studies confirmed that among different species of pepper, P. nigrum or P. longum significantly reduced the severity of pain and their analgesic potencies were mediated by piperine, which induced the inhibition of inflammatory cytokines and prostaglandin E2 or activation of calcium influx. Although piperine is found as analgesic compounds in pepper, but other components such as piperlongumine or essential oil enhanced their analgesic effects. P. nigrum, P. longum or piperine is one ingredient of analgesic formulates in combination with Zingiber officinale or Curcuma longa in human clinical studies. Therefore, formulate consists of piperine or P. nigrum in combination with analgesic herbs including Z. officinale, curcumin or ASU blend can be the subject of further clinical studies.
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences – Springer Journals
Published: Sep 1, 2021
Keywords: Piper nigrum; Piperine; Analgesic; Prostaglandins; Pain
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