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the skin and sclera occur. This disorder was thought to larization and secondary vitreous hemorrhages. Angiog- occur in a specific geographic area that extended from raphy can identify the neovascular growth, and laser the Mediterranean through the Middle East, India, and treatment can prevent such hemorrhages. Treatment of into Southeast Asia. Although a high gene frequency the surrounding ischemic retina can reduce the stimulus occurs in those areas, today thalassemia is known to for recurrence. have a worldwide distribution. It is important to be aware that ocular complications Because of prenatal hemoglobin F production, clinical may indicate the presence of an additional hemoglobin manifestations do not appear until about the sixth month abnormality. Treating that other hemoglobin abnormality of life. Without treatment, 80% of the patients with the may offer a significant benefit to such patients. When an classic form die within 5 years. Among involved infants, intraocular hemorrhage, visual field defect, or retinal the most common clinical features are pallor, irritability, neovascular change is identified, a search for an addi- growth retardation, abdominal swelling, and jaundice. tional co-existing hemoglobin abnormality is needed. If Transfusions are used to prevent the associated anemia, found, treatment directed to the manifestations of
Annals of Ophthalmology – Springer Journals
Published: Feb 25, 2007
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