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Pharmacologic and Environmental Endocrine Disruptors in the Pathogenesis of Hypospadias: a Review

Pharmacologic and Environmental Endocrine Disruptors in the Pathogenesis of Hypospadias: a Review Purpose of Review Endocrine disrupting chemicals (EDCs) potentially have a role in causing hypospadias malformation through modifiable in-utero exposure. Considering the emerging literature on the role of potential endocrine disrupting substances on the occurrence of hypospadias and the potential to inform public health efforts to prevent the occurrence of these malformations, we have summarized the current literature, identified areas of consensus, and highlighted areas that warrant further investigation. Recent Findings Pharmaceuticals, such as diethylstilbestrol, progestin fertility treatments, corticosteroids, and valproic acid, have all been associated with hypospadias risk. Data on exposure to dichlorodiphenyltrichloroethane and hexachlorobenzene pesti- cides, as well as non-persistent pollutants, particularly phthalates, is less consistent but still compelling. Summary Improving exposure assessment, standardizing sample timing to relevant developmental windows, using clear case identification and classification schemes, and elucidating dose-response relationships with EDCs will help to provide clearer evidence. Promising directions for future research include identification of subgroups with genetic hypospadias risk factors, measurement of intermediate outcomes, and study of EDC mixtures that will more accurately represent the total fetal environment. . . . . . Keywords Hypospadias Endocrine disrupting chemicals Pharmaceuticals Phthalates Pesticides In-utero Introduction hormonal pathways, may influence risk for this malformation. In particular, endocrine disrupting http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Environmental Health Reports Springer Journals

Pharmacologic and Environmental Endocrine Disruptors in the Pathogenesis of Hypospadias: a Review

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References (69)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Nature Switzerland AG
Subject
Biomedicine; Pharmacology/Toxicology; Medicine/Public Health, general; Environmental Health
eISSN
2196-5412
DOI
10.1007/s40572-018-0214-z
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review Endocrine disrupting chemicals (EDCs) potentially have a role in causing hypospadias malformation through modifiable in-utero exposure. Considering the emerging literature on the role of potential endocrine disrupting substances on the occurrence of hypospadias and the potential to inform public health efforts to prevent the occurrence of these malformations, we have summarized the current literature, identified areas of consensus, and highlighted areas that warrant further investigation. Recent Findings Pharmaceuticals, such as diethylstilbestrol, progestin fertility treatments, corticosteroids, and valproic acid, have all been associated with hypospadias risk. Data on exposure to dichlorodiphenyltrichloroethane and hexachlorobenzene pesti- cides, as well as non-persistent pollutants, particularly phthalates, is less consistent but still compelling. Summary Improving exposure assessment, standardizing sample timing to relevant developmental windows, using clear case identification and classification schemes, and elucidating dose-response relationships with EDCs will help to provide clearer evidence. Promising directions for future research include identification of subgroups with genetic hypospadias risk factors, measurement of intermediate outcomes, and study of EDC mixtures that will more accurately represent the total fetal environment. . . . . . Keywords Hypospadias Endocrine disrupting chemicals Pharmaceuticals Phthalates Pesticides In-utero Introduction hormonal pathways, may influence risk for this malformation. In particular, endocrine disrupting

Journal

Current Environmental Health Reports – Springer Journals

Published: Dec 21, 2018

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