Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Pharmacotherapy of Inpatients with Bipolar Depression

Pharmacotherapy of Inpatients with Bipolar Depression The pharmacotherapy of bipolar depression has not been well studied. Controlled studies support the efficacy of some antimanic and antidepressant drugs, but these studies usually exclude patients typically seen in nonresearch settings. The purpose of this study was to examine the pharmacotherapy of 69 inpatients with bipolar depression. More than 90% of the patients received at least one antimanic drug, and lithium was used most frequently. Only one-half of the patients received antidepressants. Three-quarters of antidepressant-treated patients received serotonin reuptake inhibitors or other nontricyclic drugs. There were few differences between antidepressant- and non-antidepressant-treated patients. Psychotic patients were more likely to receive lithium, neuroleptics, and anticholinergics, whereas nonpsychotic patients tended to receive anticonvulsants more often. Psychotic patients were also more likely to receive polypharmacy. These results suggest that polypharmacy of inpatients with bipolar depression is common, and that psychosis is an important variable in the choice of pharmacotherapy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Clinical Psychiatry Springer Journals

Pharmacotherapy of Inpatients with Bipolar Depression

Howland, Robert
Annals of Clinical Psychiatry , Volume 9 (4) – Sep 18, 2004
Download PDF
4 pages

Loading next page...
 
/lp/springer-journals/pharmacotherapy-of-inpatients-with-bipolar-depression-s4D6mxAatG
Publisher
Springer Journals
Copyright
Copyright © 1997 by American Academy of Clinical Psychiatrists
Subject
Medicine & Public Health; Neurology; Psychiatry; Psychopharmacology
ISSN
1040-1237
eISSN
1573-3238
DOI
10.1023/A:1022386424517
Publisher site
See Article on Publisher Site

Abstract

The pharmacotherapy of bipolar depression has not been well studied. Controlled studies support the efficacy of some antimanic and antidepressant drugs, but these studies usually exclude patients typically seen in nonresearch settings. The purpose of this study was to examine the pharmacotherapy of 69 inpatients with bipolar depression. More than 90% of the patients received at least one antimanic drug, and lithium was used most frequently. Only one-half of the patients received antidepressants. Three-quarters of antidepressant-treated patients received serotonin reuptake inhibitors or other nontricyclic drugs. There were few differences between antidepressant- and non-antidepressant-treated patients. Psychotic patients were more likely to receive lithium, neuroleptics, and anticholinergics, whereas nonpsychotic patients tended to receive anticonvulsants more often. Psychotic patients were also more likely to receive polypharmacy. These results suggest that polypharmacy of inpatients with bipolar depression is common, and that psychosis is an important variable in the choice of pharmacotherapy.

Journal

Annals of Clinical Psychiatry – Springer Journals

Published: Sep 18, 2004

References

  • Treatment of depression in bipolar disorder: New directions for research
    Zornberg, GL; Pope, HG
  • Can antidepressants cause mania and worsen the course of affective illness?
    Wehr, TA; Goodwin, FK
  • Induction of mania with serotonin reuptake inhibitors
    Howland, RH
  • Outcome in manic disorders
    Harrow, M; Goldberg, JF; Grossman, LS; Meltzer, HY
  • Outcome in mania
    Tohen, M; Waternaux, CM; Tsuang, MT
  • Prediction of treatment response in mania
    Taylor, MA; Abrams, R
  • A comparison of manic patient subgroups
    Verdoux, H; Bourgeosis, M
  • Treatment of manic episodes in Scandinavia: The use of neuroleptic drugs in a clinical routine setting
    Licht, RW; Gouliaev, G; Vestergaard, P; Dybbro, J; Lund, H; Merinder, L
  • The National Depressive and Manic-Depressive Association (DMDA) survey of bipolar members
    Lish, JD; Dime-Meenan, S; Whybrow, PC; Price, RA; Hirschfeld, RMA
  • Introduction
    Potter, WZ; Bowden, CL
  • Carbamazepine compared with lithium in the treatment of mania
    Small, JG; Klapper, MH; Milstein, V; Kellams, JJ; Miller, MJ; Marhenke, JD; Small, IF
  • A double-blind comparison of valproate and lithium in the treatment of acute mania
    Freeman, TW; Clothier, JL; Pazzaglia, P; Lesem, MD; Swann, AC
  • Sleep disorders in bipolar depression: Hypnotics vs sedative antidepressants
    Saiz-Ruiz, J; Cebollada, A; Ibanez, A
  • Antidepressant-associated mania: A controlled comparison with spontaneous mania
    Stoll, AL; Mayer, PV; Kolbrener, M; Goldstein, E; Suplit, B; Lucier, J; Cohen, BM; Tohen, M
  • Is there a role for neuroleptics in bipolar depression?
    Hendrick, V; Altshuler, LL; Szuba, MP
  • A comparison of fluoxetine imipramine and placebo in patients with bipolar depressive disorder
    Cohn, JB; Collins, G; Ashbrook, E; Wernicke, JF
  • Fluoxetine treatment of bipolar II depression
    Simpson, SG; DePaulo, JR
  • Induction of mania with selective serotonin re-uptake inhibitors and tricyclic antidepressants
    Peet, M
  • Comparison of manic switch onset during fluoxetine and trazodone treatment
    Terao, T
  • Monoamine oxidase inhibitors in bipolar endogenous depressives
    Quitkin, FM; McGrath, P; Liebowitz, MR; Stewart, J; Howard, A
  • Tranylcypromine versus imipramine in anergic bipolar depression
    Himmelhoch, JM; Thase, ME; Mallinger, AG; Houck, P
  • Efficacy and tolerability of moclobemide compared with imipramine in depressive disorder (DSM-III): An Austrian double-blind, multicentre study
    Baumhackl, U; Biziere, K; Fischbach, R; Geretsegger, C; Hebenstreit, G; Radmayr, E; Stabl, M
  • Bupropion's prophylactic efficacy in bipolar affective illness
    Shopsin, B
  • Bupropion in the long-term treatment of cyclic mood disorders: Mood stabilizing effects
    Wright, G; Galloway, L; Kim, J; Dalton, M; Miller, L; Stern, W
  • Bupropion as a promising approach to rapid cycling bipolar II disorder
    Haykal, RF; Akiskal, HS
  • A double-blind trial of bupropion versus desipramine for bipolar depression
    Sachs, GS; Lafer, B; Stoll, AL; Banov, M; Thibault, AB; Tohen, M; Rosenbaum, JF
  • Bupropion in the treatment of bipolar disorders: The same old story?
    Fogelson, DL; Bystritsky, A; Pasnau, R
  • A comprehensive review of cyclothymic disorder
    Howland, RH; Thase, ME