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Pluripotency of spermatogonial stem cells from adult mouse testis

Pluripotency of spermatogonial stem cells from adult mouse testis Some cells in newborn mouse testis are — like embryonic stem cells — able to generate many different tissue types. Guan et al. have discovered that these cells persist in the adult. Sperm-producing stem cells from mouse adult testis can grow as heart, nerve or muscle cells in the right conditions. If similar multipotent adult germline stem cells (maGSCs) can be isolated from humans — perhaps by simple testicular biopsy — they might provide an alternative source of genetically matched therapeutic cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

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References (30)

Publisher
Springer Journals
Copyright
Copyright © 2006 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/nature04697
Publisher site
See Article on Publisher Site

Abstract

Some cells in newborn mouse testis are — like embryonic stem cells — able to generate many different tissue types. Guan et al. have discovered that these cells persist in the adult. Sperm-producing stem cells from mouse adult testis can grow as heart, nerve or muscle cells in the right conditions. If similar multipotent adult germline stem cells (maGSCs) can be isolated from humans — perhaps by simple testicular biopsy — they might provide an alternative source of genetically matched therapeutic cells.

Journal

NatureSpringer Journals

Published: Mar 24, 2006

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