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Possibilità e limiti di impiego dei sostituti ossei in chirurgia vertebrale

Possibilità e limiti di impiego dei sostituti ossei in chirurgia vertebrale Spine fusion is considered to be the gold standard for the treatment of most degenerative and traumatic spinal conditions. Bone graft is still the best choice to achieve fusion and currently autologous and allograft bone are the main sources for bone grafting procedures. Autologous bone has by far the most osteogenic potential, but it is limited and it can lead to a donor site pain condition. Allograft bone is an important source when structural or large volumes of grafts are required. Concerns related to the use of both autografts and allografts has led to the search for alternatives, but synthetic bone graft substitutes as yet offer only a partial solution to the management of localized bone loss. They possess some of the desired mechanical qualities of bone as well as osteointegrative/conductive properties, but are largely reliant on viable periosteum/bone for their success. The advent of composite synthetic bone graft substitutes and biologically active factors is moving closer to the goal of obtaining a synthetic bone graft substitute that mimics the native bone in both mechanical and osteogenic properties. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archivio di Ortopedia e Reumatologia Springer Journals

Possibilità e limiti di impiego dei sostituti ossei in chirurgia vertebrale

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Publisher
Springer Journals
Copyright
Copyright © 2012 by Springer-Verlag Italia
Subject
Medicine & Public Health; Orthopedics
ISSN
0390-7368
eISSN
1592-7113
DOI
10.1007/s10261-012-0030-1
Publisher site
See Article on Publisher Site

Abstract

Spine fusion is considered to be the gold standard for the treatment of most degenerative and traumatic spinal conditions. Bone graft is still the best choice to achieve fusion and currently autologous and allograft bone are the main sources for bone grafting procedures. Autologous bone has by far the most osteogenic potential, but it is limited and it can lead to a donor site pain condition. Allograft bone is an important source when structural or large volumes of grafts are required. Concerns related to the use of both autografts and allografts has led to the search for alternatives, but synthetic bone graft substitutes as yet offer only a partial solution to the management of localized bone loss. They possess some of the desired mechanical qualities of bone as well as osteointegrative/conductive properties, but are largely reliant on viable periosteum/bone for their success. The advent of composite synthetic bone graft substitutes and biologically active factors is moving closer to the goal of obtaining a synthetic bone graft substitute that mimics the native bone in both mechanical and osteogenic properties.

Journal

Archivio di Ortopedia e Reumatologia – Springer Journals

Published: Dec 30, 2012

References

  • Spinal fusion in the United States: analysis of trends from 1998 to 2008
    Rajaee, S.S.; Bae, H.W.; Kanim, L.E.
  • Bone graft materials
    Bauer, T.W.; Muschler, G.F.
  • Bone grafting alternatives in spinal surgery
    Vaccaro, A.R.; Chiba, K.; Heller, J.G.
  • The biology of posterolateral lumbar spinal fusion
    Boden, S.D.
  • Contemporary bone graft physiology and surgery
    Prolo, D.J.; Rodrigo, J.J.
  • Osteoconductive bone graft extenders in posterolateral thoracolumbar spinal fusion: a systematic review
    Alsaleh, K.A.; Tougas, C.A.; Roffey, D.M.; Wai, E.K.
  • Bone graft substitutes: What are the options?
    Dinopoulos, H.; Dimitriou, R.; Giannoudis, P.V.
  • Physical and biological aspects of repair in dog cortical-bone transplants
    Enneking, W.F.; Burchardt, H.; Puhl, J.J.; Piotrowski, G.
  • Biology of bone grafts
    Stevenson, S.
  • Iliac crest bone graft harvest donor site morbidity. A statistical evaluation
    Banwart, J.C.; Asher, M.A.; Hassanein, R.S.
  • Innesti e sostituti ossei
    Brambilla, S.
  • Bone transplantation and human immunodeficiency virus. An estimate of risk of acquired immunodeficiency syndrome (AIDS)
    Buck, B.E.; Malinin, T.I.; Brown, M.D.
  • Bone banking
    Tomford, W.W.; Mankin, H.J.
  • Allograft bone. The influence of processing on safety and performance
    Boyce, T.; Edwards, J.; Scarborough, N.
  • The culture of human osteoblasts upon bone graft substitutes
    Begley, C.T.; Doherty, M.J.; Hankey, D.P.; Wilson, D.J.
  • Enhancement of the in vivo osteogenic potential of marrow/hydroxyapatite composites by bovine bone morphogenetic protein
    Noshi, T.; Yoshikawa, T.; Ikeuchi, M.
  • Unitary bioresorbable cage/core bone graft substitutes for spinal arthrodesis coextruded from polycaprolactone biocomposites
    Ergun, A.; Chung, R.; Ward, D.
  • The first clinical trial of beta-calcium pyrophosphate as a novel bone graft extender in instrumented posterolateral lumbar fusion
    Lee, J.H.; Chang, B.S.; Jeung, U.O.
  • The use of coralline hydroxyapatite for interbody spinal fusions
    Thalgott, J.S.; Fritts, K.; Giuffre, J.M.; Timlin, M.
  • Spinal fusion surgery: animal models for tissue-engineered bone constructs
    Khan, S.N.; Lane, J.M.
  • Effects of a perfusion bioreactor activated novel bone substitute in spine fusion in sheep
    Sørensen, J.R.; Koroma, K.E.; Ding, M.
  • Demineralized bone matrix as an osteoinductive biomaterial and in vitro predictors of its biological potential
    Katz, J.M.; Nataraj, C.; Jaw, R.
  • Bioactive and osteoinductive bone graft substitutes: definitions, facts and myths
    Blokhuis, T.J.; Arts, J.J.
  • The role of a composite, DBM and bone marrow in the treatment of osseous defects
    Tiedeman, J.J.; Garvin, K.L.; Kile, T.A.; Connolly, J.F.
  • Growth factor stimulation of bone healing. Effects on osteoblasts, osteomies, and implants fixation
    Lind, M.
  • Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial
    Boden, S.D.; Kang, J.; Sandhu, H.; Heller, J.G.
  • Cervical interbody fusion cages: an animal model with and without bone morphogeneticprotein
    Zdeblick, T.A.; Ghanayem, A.J.; Rapoff, A.J.
  • Histologic evaluation of the efficacy of rhBMP-2 compared with autograft bone in sheep spinal anterior interbody fusion
    Sandhu, H.S.; Toth, J.M.; Diwan, A.D.
  • Laparoscopic anterior spinal arthrodesis with rhBMP-2 in a titanium interbody threaded cage
    Boden, S.D.; Martin, G.J.; Horton, W.C.
  • The effects of BMP-7 in a rat posterolateral intertransverse process fusion model
    Salamon, M.L.; Althausen, P.L.; Gupta, M.C.; Laubach, J.
  • Efficacy of interspinous process lumbar fusion with recombinant human bone morphogenetic protein-2 delivered with a synthetic polymer and -tricalcium phosphate in a rabbit model
    Matsumoto, T.; Toyoda, H.; Dohzono, S.
  • RhBMP-2 use in lumbar fusion surgery is associated with transient immediate post-operative leg pain
    Rowan, F.E.; O’Malley, N.; Poynton, A.
  • Six-year outcomes of anterior lumbar interbody arthrodesis with use of interbody fusion cages and recombinant human bone morphogenetic protein-2
    Burkus, J.K.; Gornet, M.F.; Schuler, T.C.
  • Posterior lumbar interbody fusion using recombinant human bone morphogenetic protein type 2 with cylindrical interbody cages
    Haid, R.W.; Branch, C.L.; Alexander, J.T.; Burkus, J.K.
  • Efficacy of autologous iliac crest bone graft and bone morphogenetic proteins for posterolateral fusion of lumbar spine: a metaanalysis of the results
    Papakostidis, C.; Kontakis, G.; Bhandari, M.; Giannoudis, P.V.
  • Complications of anterior cervical discectomy and fusion using recombinant human bone morphogenetic protein-2
    Vaidya, R.; Carp, J.; Sethi, A.
  • Osteoinductive molecules in orthopaedics: basic science and preclinical studies
    Yoon, S.T.; Boden, S.D.
  • Reconstruction of goat tibial defects using an injectable tricalcium phosphate/chitosan in combination with autologous platelet-rich plasma
    Bi, L.; Cheng, W.; Fan, H.; Pei, G.
  • Influence of platelet-rich plasma on the anterior fusion in spinal injuries: a qualitative and quantitative analysis using computer tomography
    Hartmann, E.K.; Heintel, T.; Morrison, R.H.; Weckbach, A.
  • Platelet-rich plasma impairs osteoclast generation from human precursors of peripheral blood
    Cenni, E.; Avnet, S.; Fotia, C.
  • Evaluation of autologous platelet concentrate for intertransverse lumbar fusion
    Acebal-Cortina, G.; Suárez-Suárez, M.A.; García-Menéndez, C.
  • The function of bone marrow in the incorporation of bone graft
    Burwell, R.G.
  • The clinical use of combined xenografts of bone and autologous red marrow. A preliminary report
    Salama, R.; Weissman, S.L.
  • Development of an osteogenic bone marrow preparation
    Connolly, J.F.; Guse, R.; Lippiello, L.; Dehne, R.