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Postinjury Multiple Organ Failure The Evolving Syndrome of Multiple Organ Failure into PICS-CCI

Postinjury Multiple Organ Failure : The Evolving Syndrome of Multiple Organ Failure into PICS-CCI [Multiple organ failure (MOF) emerged over four decades ago with the advent of intensive care units (ICUs). Over the ensuing decades with ongoing fundamental advances in trauma and ICU care, this syndrome has evolved from being a fulminant progression of organ failure leading to early ICU death to now being a lingering chronic critical illness (CCI) leading to frailty, long-term disabilities, and indolent post-ICU death. In 2012, the term Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) was coined to describe this new CCI MOF phenotype and to provide a mechanistic framework in which to study CCI in surgical ICU patients. The chapter will discuss the evolving epidemiology and pathobiology of MOF through a series of conceptual paradigms including (a) septic auto-cannibalism, (b) sepsis syndrome, (c) abdominal compartment syndrome, and (d) the SIRS/CARS paradigm. It will then describe how modern trauma and ICU care have largely eliminated in-hospital MOF deaths, but have unfortunately created an epidemic of PICS-CCI survivors who have dismal long-term outcomes. It will conclude by discussing ongoing research efforts over the past 5 years to prospectively study the long-term outcome of PICS-CCI survivors and obtain serial biomarkers to gain insight into its underlying pathobiology.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Postinjury Multiple Organ Failure The Evolving Syndrome of Multiple Organ Failure into PICS-CCI

Part of the Hot Topics in Acute Care Surgery and Trauma Book Series
Editors: Balogh, Zsolt J.; Coimbra, Raul; Di Saverio, Salomone; Kirkpatrick, Andrew W.; Coccolini, Federico
Moore, Frederick A.
Postinjury Multiple Organ Failure — Mar 17, 2022
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Publisher
Springer International Publishing
Copyright
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022
ISBN
978-3-030-92240-5
Pages
51 –66
DOI
10.1007/978-3-030-92241-2_5
Publisher site
See Chapter on Publisher Site

Abstract

[Multiple organ failure (MOF) emerged over four decades ago with the advent of intensive care units (ICUs). Over the ensuing decades with ongoing fundamental advances in trauma and ICU care, this syndrome has evolved from being a fulminant progression of organ failure leading to early ICU death to now being a lingering chronic critical illness (CCI) leading to frailty, long-term disabilities, and indolent post-ICU death. In 2012, the term Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) was coined to describe this new CCI MOF phenotype and to provide a mechanistic framework in which to study CCI in surgical ICU patients. The chapter will discuss the evolving epidemiology and pathobiology of MOF through a series of conceptual paradigms including (a) septic auto-cannibalism, (b) sepsis syndrome, (c) abdominal compartment syndrome, and (d) the SIRS/CARS paradigm. It will then describe how modern trauma and ICU care have largely eliminated in-hospital MOF deaths, but have unfortunately created an epidemic of PICS-CCI survivors who have dismal long-term outcomes. It will conclude by discussing ongoing research efforts over the past 5 years to prospectively study the long-term outcome of PICS-CCI survivors and obtain serial biomarkers to gain insight into its underlying pathobiology.]

Published: Mar 17, 2022

Keywords: MOF; Septic auto-cannibalism; Sepsis syndrome; SIRS/CARS; Abdominal compartment syndrome; CCI; PICS

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