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Postinjury Multiple Organ Failure The Pathomechanism of Post-Injury Multiple Organ Dysfunction Syndrome (MODS)

Postinjury Multiple Organ Failure : The Pathomechanism of Post-Injury Multiple Organ Dysfunction... [Multiple organ dysfunction syndrome (MODS) represents one of the prominent cause of mortality and morbidity in critically ill patients. The understanding of MODS pathophysiology has progressively advanced over time; however, several aspects remain uncertain. Numerous different insults may represent the initial triggers of the immune system. However, MODS is characterized by the loss of the normal homeostasis between the pro- and anti-inflammatory system resulting in an uncontrolled activation of the inflammatory response. The mechanism and cellular pathophysiology involved in the transition from a physiological inflammatory response to MODS remain unclear. In this chapter, we aimed to provide an overview of the current knowledge regarding the pathophysiology of MODS, to describe the organ-specific mechanism of dysfunction, to highlight the potential nosocomial hit, to outline possible predictor of MODS and to review some of promising new target treatment.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Postinjury Multiple Organ Failure The Pathomechanism of Post-Injury Multiple Organ Dysfunction Syndrome (MODS)

Part of the Hot Topics in Acute Care Surgery and Trauma Book Series
Editors: Balogh, Zsolt J.; Coimbra, Raul; Di Saverio, Salomone; Kirkpatrick, Andrew W.; Coccolini, Federico
Brogi, Etrusca; Coccolini, Federico; Forfori, Francesco
Postinjury Multiple Organ Failure — Mar 17, 2022
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Publisher
Springer International Publishing
Copyright
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022
ISBN
978-3-030-92240-5
Pages
9 –31
DOI
10.1007/978-3-030-92241-2_2
Publisher site
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Abstract

[Multiple organ dysfunction syndrome (MODS) represents one of the prominent cause of mortality and morbidity in critically ill patients. The understanding of MODS pathophysiology has progressively advanced over time; however, several aspects remain uncertain. Numerous different insults may represent the initial triggers of the immune system. However, MODS is characterized by the loss of the normal homeostasis between the pro- and anti-inflammatory system resulting in an uncontrolled activation of the inflammatory response. The mechanism and cellular pathophysiology involved in the transition from a physiological inflammatory response to MODS remain unclear. In this chapter, we aimed to provide an overview of the current knowledge regarding the pathophysiology of MODS, to describe the organ-specific mechanism of dysfunction, to highlight the potential nosocomial hit, to outline possible predictor of MODS and to review some of promising new target treatment.]

Published: Mar 17, 2022

Keywords: Multiple organ failure; Pathophysiology; Trauma; Sepsis; Systemic inflammatory response syndrome; Inflammation; Cytokines; Organ dysfunction; Shock; Resuscitation; Target therapy

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