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Postinjury Multiple Organ Failure The Principles of Treatment, Modern Therapeutic Targets

Postinjury Multiple Organ Failure : The Principles of Treatment, Modern Therapeutic Targets [Patients suffering from severe multiple trauma injuries may develop multiple organ failure and polycompartment syndrome as early or mid-term complications. Excessive inflammatory response as a consequence of a high energy injury along with side effects of resuscitative treatments are the pathophysiological pathways to these clinical conditions, leading to increased systemic permeability. Patients undergoing multiple organ failure usually need sedation and mechanical ventilation for coexistent respiratory failure, fluid and vasoactive drugs as first-line treatment for circulatory collapse, artificial nutrition and often extracorporeal multiorgan supports to gain time avoiding death for treatment failure. All these treatments must be titrated to judicious targets, usually accepting compromises between the optimal target for a single organ failure, and the detrimental effect on multiple organ failure. Authors try to explain the principles of this therapeutic approach aimed at being an ally of the patient’s physiological response to the injury, and not a second injury itself.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Postinjury Multiple Organ Failure The Principles of Treatment, Modern Therapeutic Targets

Part of the Hot Topics in Acute Care Surgery and Trauma Book Series
Editors: Balogh, Zsolt J.; Coimbra, Raul; Di Saverio, Salomone; Kirkpatrick, Andrew W.; Coccolini, Federico
Gamberini, Emiliano; Coccolini, Federico; Scognamiglio, Giovanni; Agnoletti, Vanni
Postinjury Multiple Organ Failure — Mar 17, 2022
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Publisher
Springer International Publishing
Copyright
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022
ISBN
978-3-030-92240-5
Pages
89 –104
DOI
10.1007/978-3-030-92241-2_9
Publisher site
See Chapter on Publisher Site

Abstract

[Patients suffering from severe multiple trauma injuries may develop multiple organ failure and polycompartment syndrome as early or mid-term complications. Excessive inflammatory response as a consequence of a high energy injury along with side effects of resuscitative treatments are the pathophysiological pathways to these clinical conditions, leading to increased systemic permeability. Patients undergoing multiple organ failure usually need sedation and mechanical ventilation for coexistent respiratory failure, fluid and vasoactive drugs as first-line treatment for circulatory collapse, artificial nutrition and often extracorporeal multiorgan supports to gain time avoiding death for treatment failure. All these treatments must be titrated to judicious targets, usually accepting compromises between the optimal target for a single organ failure, and the detrimental effect on multiple organ failure. Authors try to explain the principles of this therapeutic approach aimed at being an ally of the patient’s physiological response to the injury, and not a second injury itself.]

Published: Mar 17, 2022

Keywords: Polycompartment syndrome; Multiple organ failure; Systemic increased permeability; Shock; Resuscitation

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