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Production of a monoclonal antibody specific for Hodgkin and Sternberg–Reed cells of Hodgkin's disease and a subset of normal lymphoid cells

Production of a monoclonal antibody specific for Hodgkin and Sternberg–Reed cells of Hodgkin's... The origins of the neoplastic cells in Hodgkin's lymphoma1, the Hodgkin (H) and Sternberg–Reed(SR) cells, are still obscure, and these cells appear to carry no markers found on any population of normal cells2,3. However the recent establishment of permanent Hodgkin cell lines3,4 has led to the search for tumour-specific antigens and/or for membrane markers on H and SR cells which may indicate the normal equivalent cells. Here, we describe the production of mouse monoclonal antibodies against the Hodgkin cell line L428. One hybridoma antibody, Ki-1, was found to be specific for H and SR cells of all Hodgkin's lymphomas tested and a minute, but distinct new cell population in normal tonsils and lymph nodes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Production of a monoclonal antibody specific for Hodgkin and Sternberg–Reed cells of Hodgkin's disease and a subset of normal lymphoid cells

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References (18)

Publisher
Springer Journals
Copyright
Copyright © 1982 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/299065a0
Publisher site
See Article on Publisher Site

Abstract

The origins of the neoplastic cells in Hodgkin's lymphoma1, the Hodgkin (H) and Sternberg–Reed(SR) cells, are still obscure, and these cells appear to carry no markers found on any population of normal cells2,3. However the recent establishment of permanent Hodgkin cell lines3,4 has led to the search for tumour-specific antigens and/or for membrane markers on H and SR cells which may indicate the normal equivalent cells. Here, we describe the production of mouse monoclonal antibodies against the Hodgkin cell line L428. One hybridoma antibody, Ki-1, was found to be specific for H and SR cells of all Hodgkin's lymphomas tested and a minute, but distinct new cell population in normal tonsils and lymph nodes.

Journal

NatureSpringer Journals

Published: Sep 1, 1982

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