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Random with Respect to Fitness or External Selection? An Important but Often Overlooked Distinction

Random with Respect to Fitness or External Selection? An Important but Often Overlooked Distinction Mutations are often described as being “random with respect to fitness.” Here we show that the experiments used to establish randomness with respect to fitness are only capable of showing that mutations are random with respect to current external selection. Current debates about whether or not mutations are directed may be at least partially resolved by making use of this distinction. Additionally, this distinction has important mathematical, experimental, and inferential implications. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Biotheoretica Springer Journals

Random with Respect to Fitness or External Selection? An Important but Often Overlooked Distinction

Bartlett, Jonathan
Acta Biotheoretica , Volume 71 (2) – Jun 1, 2023
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Publisher
Springer Journals
Copyright
Copyright © Prof. Dr. Jan van der Hoeven stichting voor theoretische biologie 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
ISSN
0001-5342
eISSN
1572-8358
DOI
10.1007/s10441-023-09464-8
Publisher site
See Article on Publisher Site

Abstract

Mutations are often described as being “random with respect to fitness.” Here we show that the experiments used to establish randomness with respect to fitness are only capable of showing that mutations are random with respect to current external selection. Current debates about whether or not mutations are directed may be at least partially resolved by making use of this distinction. Additionally, this distinction has important mathematical, experimental, and inferential implications.

Journal

Acta Biotheoretica – Springer Journals

Published: Jun 1, 2023

Keywords: Mutation; Selection; Randomness; Directed mutation; Extended evolutionary synthesis; cyclical mutations

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