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Risk from Lithium with Acetylcholinesterase Inhibitor

Risk from Lithium with Acetylcholinesterase Inhibitor P1: GRA Annals of Clinical Psychiatry (ACLI) pp723-acli-458809 January 14, 2003 18:34 Style file version Nov. 28, 2000 ° C Annals of Clinical Psychiatry, Vol. 14, No. 4, December 2002 ( 2002) 1 1, 2 Alex A. Amante, MD and Conrad M. Swartz, PhD, MD Toxic effects can result from the combination of and lithium. Two reports (3, 4) described single- an acetylcholinesterase inhibitor (anticholinesterase) dose physostigmine administration to patients on and a lithium salt. The combination of tacrine lithium without adverse effects, but these reports did (5 mg/kg) and lithium salt (12 mEq/kg) produced not mention that laboratory animals sustained lim- seizures and brain injury in 90% of laboratory an- bic seizures and widespread brain damage following imals, apparently mediated by high levels of nitric “physostigmine doses and concentrations of blood oxide (NO) in the brain (1). These doses are rea- lithium::: similar to those considered appropriate for sonably representative of ordinary human clinical psychiatric chemotherapy” (5). use. Accordingly, there is potential risk to patients Together, lithium and tacrine increased nitric from concurrent administration of lithium carbonate oxide synthase activity in the hippocampus. Prior and tacrine, donepezil, rivastigmine, or galantamine. inhibition of this enzyme by intracerebroventricular There is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Clinical Psychiatry Springer Journals

Risk from Lithium with Acetylcholinesterase Inhibitor

Annals of Clinical Psychiatry , Volume 14 (4) – Oct 10, 2004

Risk from Lithium with Acetylcholinesterase Inhibitor

Abstract

P1: GRA Annals of Clinical Psychiatry (ACLI) pp723-acli-458809 January 14, 2003 18:34 Style file version Nov. 28, 2000 ° C Annals of Clinical Psychiatry, Vol. 14, No. 4, December 2002 ( 2002) 1 1, 2 Alex A. Amante, MD and Conrad M. Swartz, PhD, MD Toxic effects can result from the combination of and lithium. Two reports (3, 4) described single- an acetylcholinesterase inhibitor (anticholinesterase) dose physostigmine administration to patients on and a lithium salt. The combination...
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Publisher
Springer Journals
Copyright
Copyright © 2002 by American Academy of Clinical Psychiatrists
Subject
Medicine & Public Health; Neurology; Psychiatry; Psychopharmacology
ISSN
1040-1237
eISSN
1573-3238
DOI
10.1023/A:1021925318978
Publisher site
See Article on Publisher Site

Abstract

P1: GRA Annals of Clinical Psychiatry (ACLI) pp723-acli-458809 January 14, 2003 18:34 Style file version Nov. 28, 2000 ° C Annals of Clinical Psychiatry, Vol. 14, No. 4, December 2002 ( 2002) 1 1, 2 Alex A. Amante, MD and Conrad M. Swartz, PhD, MD Toxic effects can result from the combination of and lithium. Two reports (3, 4) described single- an acetylcholinesterase inhibitor (anticholinesterase) dose physostigmine administration to patients on and a lithium salt. The combination of tacrine lithium without adverse effects, but these reports did (5 mg/kg) and lithium salt (12 mEq/kg) produced not mention that laboratory animals sustained lim- seizures and brain injury in 90% of laboratory an- bic seizures and widespread brain damage following imals, apparently mediated by high levels of nitric “physostigmine doses and concentrations of blood oxide (NO) in the brain (1). These doses are rea- lithium::: similar to those considered appropriate for sonably representative of ordinary human clinical psychiatric chemotherapy” (5). use. Accordingly, there is potential risk to patients Together, lithium and tacrine increased nitric from concurrent administration of lithium carbonate oxide synthase activity in the hippocampus. Prior and tacrine, donepezil, rivastigmine, or galantamine. inhibition of this enzyme by intracerebroventricular There is

Journal

Annals of Clinical PsychiatrySpringer Journals

Published: Oct 10, 2004

References