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Risperidone and Hyponatremia: A Case Report

Risperidone and Hyponatremia: A Case Report Annals of Clinical Psychiatry, Vol. 9, No. 3, 1997 James R. Whitten, M.D.,1,3 and Valerie L. Ruehter, R.Ph., B. S. Pharm.2 A 48 year-old white male not suffering from endocrine disease or polydipsia, not taking diuretics, and suffering from no renal disease was started on risperidone and discharged on no other drug from Western Missiouri Mental Health Center (WMMHC) after an 8-day hospitalization. Seven days later he was admitted to a university medical center with gener- alized seizures, hyponatremia, respiratory failure, and rhabdomyalysis. He eventually recov- ered, was transferred back to WMMHC, and stabilized on appropriate medication. A search of the literature indicates no case reports linking risperidone to hyponatremia. It is assumed that the mechanism of hyponatremia is similar to other psychotropic medication in that it is secondary to the syndrome of inappropriate antidiuretic hormone (SIADH). KEY WORDS: Risperidone; hyponatremia; syndrome of inappropriate antidiuretic hormone (SIADH). INTRODUCTION from Janssen Pharmacentica, Inc. There is some men- tion of using risperidone in the treatment of polydipsia There is a variety of conditions that can lead to and schizophrenia in the literature (4,5) but no men- an abnormal and sustained reduction in the serum so- tion of risperidone causing hyponatremia. As http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Clinical Psychiatry Springer Journals

Risperidone and Hyponatremia: A Case Report

Whitten, James
Annals of Clinical Psychiatry , Volume 9 (3) – Sep 18, 2004
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Publisher
Springer Journals
Copyright
Copyright © 1997 by American Academy of Clinical Psychiatrists
Subject
Medicine & Public Health; Neurology; Psychiatry; Psychopharmacology
ISSN
1040-1237
eISSN
1573-3238
DOI
10.1023/A:1026286109635
Publisher site
See Article on Publisher Site

Abstract

Annals of Clinical Psychiatry, Vol. 9, No. 3, 1997 James R. Whitten, M.D.,1,3 and Valerie L. Ruehter, R.Ph., B. S. Pharm.2 A 48 year-old white male not suffering from endocrine disease or polydipsia, not taking diuretics, and suffering from no renal disease was started on risperidone and discharged on no other drug from Western Missiouri Mental Health Center (WMMHC) after an 8-day hospitalization. Seven days later he was admitted to a university medical center with gener- alized seizures, hyponatremia, respiratory failure, and rhabdomyalysis. He eventually recov- ered, was transferred back to WMMHC, and stabilized on appropriate medication. A search of the literature indicates no case reports linking risperidone to hyponatremia. It is assumed that the mechanism of hyponatremia is similar to other psychotropic medication in that it is secondary to the syndrome of inappropriate antidiuretic hormone (SIADH). KEY WORDS: Risperidone; hyponatremia; syndrome of inappropriate antidiuretic hormone (SIADH). INTRODUCTION from Janssen Pharmacentica, Inc. There is some men- tion of using risperidone in the treatment of polydipsia There is a variety of conditions that can lead to and schizophrenia in the literature (4,5) but no men- an abnormal and sustained reduction in the serum so- tion of risperidone causing hyponatremia. As

Journal

Annals of Clinical Psychiatry – Springer Journals

Published: Sep 18, 2004

References

  • Harrison's Principles of Internal Medicine
    Wilson, JD
  • Syndrome of inappropriate antidiuresis
    Kovacs, L; Robertson, GL
  • The effect of risperidone on polydypsia and hyponatremia in schizophrenia
    Landry, P
  • The P.I.P. syndrome—polydypsia, intermittant hyponatremia and psychosis—Diagnosis and therapeutic approach—A case report
    Assoulybesse, F; Seletti, B; Lamarque, I; Elghozi, D; Petijean, F
  • Risk factors for the development of hyponatremia in psychiatric inpatients
    Siegler, EL
  • Recurrent hyponatremia associated with fluoxetine and paroxetine
    Flint, AJ; Crosby, J; Genik, JL
  • Hyponatremia Associated with carbamazepine and oxcarbazepine therapy, a review
    VanAnelsvoort, T.; Bakshi, R