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Role of TP53 polymorphisms in sub-Saharan mucosal cancers

Role of TP53 polymorphisms in sub-Saharan mucosal cancers Buonaguro et al. Infectious Agents and Cancer 2010, 5(Suppl 1):A73 http://www.infectagentscancer.com/content/5/S1/A73 MEETING ABSTRACTS Open Access Role of TP53 polymorphisms in sub-Saharan mucosal cancers Franco M Buonaguro , MariaLina Tornesello, Luigi Buonaguro th From 12 International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI) Bethesda, MD, USA. 26-27 April, 2010 Background Discussion The most common TP53 gene polymorphism, which The results suggest that TP53 Arg/Arg codon 72 geno- alters amino acid sequence of the oncosuppressor p53 type is a relevant risk factor for invasive squamous cell protein, is located at the codon 72, resulting in either carcinoma of the conjunctiva and for CIN3 in the Ugan- Pro72orArg72 p53variant.Several studies have asso- dan population. ciated, with controversial results, the prevalence of the Arg allele with different types of cancer. The aim of this Distribution and role of TP53 Arg72 and Pro72 report is to analyze the role of p53 polymorphisms in alleles in cervical neoplasia two mucosal (conjunctival and genital) HPV-associated Method cancers during HIV epidemic. In the genital mucosal study, 78 penile squamous cell carcinoma biopsies (n = 17 from Uganda, n = 61 from Distribution and role of TP53 Arg72 and Pro72 Italy) and blood samples from 150 healthy controls (n = alleles in conjunctival neoplasia 57 from Uganda, n = 93 from Italy) have been analyzed Method for the arginine and proline allele distribution The study included 41 invasive conjunctival squamous cell carcinoma (ICSCC), 33 conjunctival intraepithelial Results neoplasiaofgrade 3(CIN3), 33 of moderate grade Among Ugandan cases the heterozygous, proline homo- (CIN1 and CIN2), and 115 controls from Uganda, a zygous and arginine homozygous genotype frequency sub-Saharan country with the highest incidence rate of was 41.2%, 52.9%, and 5.9%, respectively, and among conjunctival neoplasia in the world, particularly in the controls was 40.3%, 54.4%, and 5.3%, respectively era of AIDS. (P=0.9917). Conversely, among Italian cases, genotype distribution was 42.6%, 4.9%, and 52.5%, and among Results controls was 34.4%, 7.5%, and 58.1%, respectively The TP53 Arg/Arg codon 72 genotype was detected in (P = 0.5343). 21.9% of ICSCC and in 18.2% of CIN3 but only in 6% of CIN1-2 and in 5.2% of controls (P<0.05). These data Discussion show an increased risk of ICSCC (odds ratio (OR)=6.2, No significant differences in arginine and proline allele 95% confidence interval (CI): 1.6-24.6) and CIN3 distribution were observed when the cases were stratified (OR=4.1, 95% CI: 1.0-18.0) associated with TP53 Arg by HPV status. Therefore, no evidence of association homozygosity, not observed in CIN1-2 lesions (OR=0.8, between homozygosity for p53 arginine and HPV-related 95% CI: 0.1-5.1). Moreover, the frequency of the Arg or HPV-unrelated penile squamous cell carcinoma was homozygosity was similar in HIV-positive and HIV- observed. negative groups. Conclusions The overall results from the combined data of these stu- *Correspondence: irccsvir@unina.it Istituto Nazionale Tumori “Fondazione” Pascale,” Naples, Italy dies strongly suggest that (1) Arg homozygosity represents Full list of author information is available at the end of the article © 2010 Buonaguro et al; licensee BioMed Central Ltd. Buonaguro et al. Infectious Agents and Cancer 2010, 5(Suppl 1):A73 Page 2 of 2 http://www.infectagentscancer.com/content/5/S1/A73 a relevant risk factor for low-risk HPVb-related cancers, for which further co-carcinogenic factors are needed. (2) Arg homozygosity does not represent a significant risk fac- tor for high-risk HPVa-related cancers, such as penile cancers. Acknowledgements This article has been published as part of Infectious Agents and Cancer th Volume 5 Supplement 1, 2010: Proceedings of the 12 International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI). The full contents of the supplement are available online at http://www.biomedcentral.com/1750-9378/5?issue=S1. Published: 11 October 2010 doi:10.1186/1750-9378-5-S1-A73 Cite this article as: Buonaguro et al.: Role of TP53 polymorphisms in sub-Saharan mucosal cancers. Infectious Agents and Cancer 2010 5(Suppl 1):A73. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color figure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Infectious Agents and Cancer Springer Journals

Role of TP53 polymorphisms in sub-Saharan mucosal cancers

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Springer Journals
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Copyright © 2010 by Buonaguro et al; licensee BioMed Central Ltd.
Subject
Biomedicine; Cancer Research; Infectious Diseases; Oncology
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1750-9378
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10.1186/1750-9378-5-S1-A73
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Abstract

Buonaguro et al. Infectious Agents and Cancer 2010, 5(Suppl 1):A73 http://www.infectagentscancer.com/content/5/S1/A73 MEETING ABSTRACTS Open Access Role of TP53 polymorphisms in sub-Saharan mucosal cancers Franco M Buonaguro , MariaLina Tornesello, Luigi Buonaguro th From 12 International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI) Bethesda, MD, USA. 26-27 April, 2010 Background Discussion The most common TP53 gene polymorphism, which The results suggest that TP53 Arg/Arg codon 72 geno- alters amino acid sequence of the oncosuppressor p53 type is a relevant risk factor for invasive squamous cell protein, is located at the codon 72, resulting in either carcinoma of the conjunctiva and for CIN3 in the Ugan- Pro72orArg72 p53variant.Several studies have asso- dan population. ciated, with controversial results, the prevalence of the Arg allele with different types of cancer. The aim of this Distribution and role of TP53 Arg72 and Pro72 report is to analyze the role of p53 polymorphisms in alleles in cervical neoplasia two mucosal (conjunctival and genital) HPV-associated Method cancers during HIV epidemic. In the genital mucosal study, 78 penile squamous cell carcinoma biopsies (n = 17 from Uganda, n = 61 from Distribution and role of TP53 Arg72 and Pro72 Italy) and blood samples from 150 healthy controls (n = alleles in conjunctival neoplasia 57 from Uganda, n = 93 from Italy) have been analyzed Method for the arginine and proline allele distribution The study included 41 invasive conjunctival squamous cell carcinoma (ICSCC), 33 conjunctival intraepithelial Results neoplasiaofgrade 3(CIN3), 33 of moderate grade Among Ugandan cases the heterozygous, proline homo- (CIN1 and CIN2), and 115 controls from Uganda, a zygous and arginine homozygous genotype frequency sub-Saharan country with the highest incidence rate of was 41.2%, 52.9%, and 5.9%, respectively, and among conjunctival neoplasia in the world, particularly in the controls was 40.3%, 54.4%, and 5.3%, respectively era of AIDS. (P=0.9917). Conversely, among Italian cases, genotype distribution was 42.6%, 4.9%, and 52.5%, and among Results controls was 34.4%, 7.5%, and 58.1%, respectively The TP53 Arg/Arg codon 72 genotype was detected in (P = 0.5343). 21.9% of ICSCC and in 18.2% of CIN3 but only in 6% of CIN1-2 and in 5.2% of controls (P<0.05). These data Discussion show an increased risk of ICSCC (odds ratio (OR)=6.2, No significant differences in arginine and proline allele 95% confidence interval (CI): 1.6-24.6) and CIN3 distribution were observed when the cases were stratified (OR=4.1, 95% CI: 1.0-18.0) associated with TP53 Arg by HPV status. Therefore, no evidence of association homozygosity, not observed in CIN1-2 lesions (OR=0.8, between homozygosity for p53 arginine and HPV-related 95% CI: 0.1-5.1). Moreover, the frequency of the Arg or HPV-unrelated penile squamous cell carcinoma was homozygosity was similar in HIV-positive and HIV- observed. negative groups. Conclusions The overall results from the combined data of these stu- *Correspondence: irccsvir@unina.it Istituto Nazionale Tumori “Fondazione” Pascale,” Naples, Italy dies strongly suggest that (1) Arg homozygosity represents Full list of author information is available at the end of the article © 2010 Buonaguro et al; licensee BioMed Central Ltd. Buonaguro et al. Infectious Agents and Cancer 2010, 5(Suppl 1):A73 Page 2 of 2 http://www.infectagentscancer.com/content/5/S1/A73 a relevant risk factor for low-risk HPVb-related cancers, for which further co-carcinogenic factors are needed. (2) Arg homozygosity does not represent a significant risk fac- tor for high-risk HPVa-related cancers, such as penile cancers. Acknowledgements This article has been published as part of Infectious Agents and Cancer th Volume 5 Supplement 1, 2010: Proceedings of the 12 International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI). The full contents of the supplement are available online at http://www.biomedcentral.com/1750-9378/5?issue=S1. Published: 11 October 2010 doi:10.1186/1750-9378-5-S1-A73 Cite this article as: Buonaguro et al.: Role of TP53 polymorphisms in sub-Saharan mucosal cancers. Infectious Agents and Cancer 2010 5(Suppl 1):A73. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color figure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit

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Infectious Agents and Cancer – Springer Journals

Published: Oct 11, 2010

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