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Selected Topics in Cancer ModelingA Game Theoretical Perspective on the Somatic Evolution of cancer

Selected Topics in Cancer Modeling: A Game Theoretical Perspective on the Somatic Evolution of... A Game Theoretical Perspective on the Somatic Evolution of Cancer David Basanta and Andreas Deutsch Technische Universit¨ at Dresden, Zentrum fur ¨ Informationsdienste und Hochleistungsrechnen, N¨ othnitzer-str. 46, 01187, Dresden, Germany {david.basanta, andreas.deutsch}@tu-dresden.de 5.1 Introduction Environmental and genetic mutations can transform the cells in a co-operating healthy tissue into an ecosystem of individualistic tumour cells that compete for space and resources [1, 2, 3]. If we consider a tumour as an ecosystem it is possible to utilise tools traditionally used by ecologists to study the evolu- tion of a population in which there is some degree of phenotypical diversity. One such tool is evolutionary game theory (EGT) which merges traditional game theory with population biology [4]. It allows the prediction of successful phenotypes and their adaptation to environmental selection forces. EGT is considered as a promising tool in which to frame oncological problems [5] and has been recently made more relevant by phenotypic studies of carcinogenesis such as the ones by Hanahan, Weinberg and colleagues [6, 7]. Game theory (GT) was introduced by von Neumann and Morgenstern as an instrument to study human behaviour [8, 9]. A game describes the inter- actions of two or more players that follow http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Selected Topics in Cancer ModelingA Game Theoretical Perspective on the Somatic Evolution of cancer

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Publisher
Birkhäuser Boston
Copyright
© Birkhäuser Boston 2008
ISBN
978-0-8176-4712-4
Pages
1 –16
DOI
10.1007/978-0-8176-4713-1_5
Publisher site
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Abstract

A Game Theoretical Perspective on the Somatic Evolution of Cancer David Basanta and Andreas Deutsch Technische Universit¨ at Dresden, Zentrum fur ¨ Informationsdienste und Hochleistungsrechnen, N¨ othnitzer-str. 46, 01187, Dresden, Germany {david.basanta, andreas.deutsch}@tu-dresden.de 5.1 Introduction Environmental and genetic mutations can transform the cells in a co-operating healthy tissue into an ecosystem of individualistic tumour cells that compete for space and resources [1, 2, 3]. If we consider a tumour as an ecosystem it is possible to utilise tools traditionally used by ecologists to study the evolu- tion of a population in which there is some degree of phenotypical diversity. One such tool is evolutionary game theory (EGT) which merges traditional game theory with population biology [4]. It allows the prediction of successful phenotypes and their adaptation to environmental selection forces. EGT is considered as a promising tool in which to frame oncological problems [5] and has been recently made more relevant by phenotypic studies of carcinogenesis such as the ones by Hanahan, Weinberg and colleagues [6, 7]. Game theory (GT) was introduced by von Neumann and Morgenstern as an instrument to study human behaviour [8, 9]. A game describes the inter- actions of two or more players that follow

Published: Aug 21, 2008

Keywords: Angiogenic Factor; Invasive Phenotype; Evolutionarily Stable Strategy; Evolutionary Game Theory; Glycolytic Metabolism

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