Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Selected Topics in Cancer ModelingNonlinear Modeling and Simulation of Tumor Growth

Selected Topics in Cancer Modeling: Nonlinear Modeling and Simulation of Tumor Growth Nonlinear Modeling and Simulation of Tumor Growth 1,4,5 1,2 3 Vittorio Cristini, Hermann B. Frieboes, Xiaongrong Li, John S. 2,3 1 1,4 2 Lowengrub, Paul Macklin, Sandeep Sanga, Steven M. Wise, and Xiaoming Zheng School of Health Information Sciences, University of Texas Health Science Center at Houston, TX 77030, USA vittorio.cristini@uth.tmc.edu Department of Mathematics, University of California, Irvine, CA 92697, USA lowengrb@math.uci.edu Department of Biomedical Engineering, University of California, Irvine, Department of Biomedical Engineering, University of Texas, Austin, TX 78712, USA MD Anderson Cancer Center, University of Texas, Houston, TX 77030, USA 6.1 Introduction The effects of the interaction between cellular- and tumor-scale processes on cancer progression and treatment response remain poorly understood (for in- stance, the crucial role of the microenvironment in cancer growth and invasion [94, 64, 183, 182, 159, 109, 65, 165]). Three-dimensional tissue morphology, cell phenotype, and molecular phenomena are intricately coupled; they influence cancer invasion potential by controlling tumor-cell proliferation and migration [77, 186, 197]. Hypoxia [87, 209, 185, 69, 90], acidosis [90, 198, 95], and associ- ated diffusion gradients, caused by heterogeneous delivery of oxygen and nutri- ents and removal of metabolites [103, 102] due to highly disorganized microvas- culature [91, 105] and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Selected Topics in Cancer ModelingNonlinear Modeling and Simulation of Tumor Growth

Download PDF
69 pages

Loading next page...
 
/lp/springer-journals/selected-topics-in-cancer-modeling-nonlinear-modeling-and-simulation-PnYXPLeNMV
Publisher
Birkhäuser Boston
Copyright
© Birkhäuser Boston 2008
ISBN
978-0-8176-4712-4
Pages
1 –69
DOI
10.1007/978-0-8176-4713-1_6
Publisher site
See Chapter on Publisher Site

Abstract

Nonlinear Modeling and Simulation of Tumor Growth 1,4,5 1,2 3 Vittorio Cristini, Hermann B. Frieboes, Xiaongrong Li, John S. 2,3 1 1,4 2 Lowengrub, Paul Macklin, Sandeep Sanga, Steven M. Wise, and Xiaoming Zheng School of Health Information Sciences, University of Texas Health Science Center at Houston, TX 77030, USA vittorio.cristini@uth.tmc.edu Department of Mathematics, University of California, Irvine, CA 92697, USA lowengrb@math.uci.edu Department of Biomedical Engineering, University of California, Irvine, Department of Biomedical Engineering, University of Texas, Austin, TX 78712, USA MD Anderson Cancer Center, University of Texas, Houston, TX 77030, USA 6.1 Introduction The effects of the interaction between cellular- and tumor-scale processes on cancer progression and treatment response remain poorly understood (for in- stance, the crucial role of the microenvironment in cancer growth and invasion [94, 64, 183, 182, 159, 109, 65, 165]). Three-dimensional tissue morphology, cell phenotype, and molecular phenomena are intricately coupled; they influence cancer invasion potential by controlling tumor-cell proliferation and migration [77, 186, 197]. Hypoxia [87, 209, 185, 69, 90], acidosis [90, 198, 95], and associ- ated diffusion gradients, caused by heterogeneous delivery of oxygen and nutri- ents and removal of metabolites [103, 102] due to highly disorganized microvas- culature [91, 105] and

Published: Aug 21, 2008

Keywords: Necrotic Core; Antiangiogenic Therapy; Noncancerous Tissue; Endothelial Cell Density; Tumor Morphology

There are no references for this article.