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Sexual Dysfunction Associated with the Treatment of Depression: A Placebo-Controlled Comparison of Bupropion Sustained Release and Sertraline Treatment

Sexual Dysfunction Associated with the Treatment of Depression: A Placebo-Controlled Comparison... This study compared the sexual functioning effects as well as the safety and efficacy of bupropion sustained release (bupropion SR) and sertraline. Three hundred sixty-four patients with normal sexual functioning and recurrent major depression were treated with bupropion SR (150–400 mg/day), sertraline (50–200 mg/day), or placebo for 8 weeks in this randomized, double-blind, multicenter study. Patients' depression, sexual functioning, and overall safety were assessed at regular clinic visits. Significantly (P < 0.05) more patients treated with sertraline experienced orgasm dysfunction compared with patients treated with bupropion SR or placebo. Bupropion SR, but not sertraline, was statistically significantly superior to placebo in improving scores on all depression scales by the end of the study. Headache occurred with similar frequency in all groups. Gastrointestinal disturbances occurred more frequently with sertraline; insomnia and agitation occurred more frequently with bupropion SR. Small decreases in mean weight were seen with both active treatments; the placebo group experienced a minor increase in mean weight. Both bupropion SR and sertraline were generally well tolerated, although sertraline was more often associated with sexual dysfunction. Bupropion SR, but not sertraline, was statistically superior to placebo in relieving depression by the end of the study. Bupropion SR may offer advantages over sertraline in treating depressed patients concerned with sexual functioning. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Clinical Psychiatry Springer Journals

Sexual Dysfunction Associated with the Treatment of Depression: A Placebo-Controlled Comparison of Bupropion Sustained Release and Sertraline Treatment

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Publisher
Springer Journals
Copyright
Copyright © 1999 by American Academy of Clinical Psychiatrists
Subject
Medicine & Public Health; Neurology; Psychiatry; Psychopharmacology
ISSN
1040-1237
eISSN
1573-3238
DOI
10.1023/A:1022309428886
Publisher site
See Article on Publisher Site

Abstract

This study compared the sexual functioning effects as well as the safety and efficacy of bupropion sustained release (bupropion SR) and sertraline. Three hundred sixty-four patients with normal sexual functioning and recurrent major depression were treated with bupropion SR (150–400 mg/day), sertraline (50–200 mg/day), or placebo for 8 weeks in this randomized, double-blind, multicenter study. Patients' depression, sexual functioning, and overall safety were assessed at regular clinic visits. Significantly (P < 0.05) more patients treated with sertraline experienced orgasm dysfunction compared with patients treated with bupropion SR or placebo. Bupropion SR, but not sertraline, was statistically significantly superior to placebo in improving scores on all depression scales by the end of the study. Headache occurred with similar frequency in all groups. Gastrointestinal disturbances occurred more frequently with sertraline; insomnia and agitation occurred more frequently with bupropion SR. Small decreases in mean weight were seen with both active treatments; the placebo group experienced a minor increase in mean weight. Both bupropion SR and sertraline were generally well tolerated, although sertraline was more often associated with sexual dysfunction. Bupropion SR, but not sertraline, was statistically superior to placebo in relieving depression by the end of the study. Bupropion SR may offer advantages over sertraline in treating depressed patients concerned with sexual functioning.

Journal

Annals of Clinical Psychiatry – Springer Journals

Published: Sep 30, 2004

References

  • Managing antidepressant side effects
    Settle, EC
  • Management of antidepressant-induced side effects: a practical guide for the clinician
    Pollack, MH; Rosenbaum, JF
  • Antidepressant drug therapy and sexual dysfunction in men: a review
    Mitchell, JE; Popkin, MK
  • Sexual side effects of antidepressant drugs
    DeLeo, D; Magni, G
  • Fluoxetine-induced sexual dysfunction
    Herman, JB; Brotman, AW; Pollack, MH; Falk, WE; Biederman, J; Rosenbaum, JF
  • Overview of sexual dysfunction complicating the treatment of depression
    Segraves, RT
  • Antidotes for depression-induced sexual dysfunction
    Hopkins, HS
  • Fluoxetine-induced sexual dysfunction in an open trial of yohimbine
    Jacobsen, FM
  • Current Psychiatric Therapy
    Nitenson, NC; Cole, JO
  • Mianserin, a 5-HT2a/2c and α2 antagonist, in the treatment of sexual dysfunction induced by serotonin reuptake inhibitors
    Aizenberg, D; Gur, S; Zemishlany, Z; Granek, M; Jeczmien, P; Weizman, A
  • The role of serotonin in sexual dysfunction: fluoxetine-associated orgasm dysfunction
    Zajecka, J; Fawcett, J; Schaff, M; Jeffriess, H; Guy, C
  • Treatment of tricyclic antidepressant-induced orgasmic inhibition with cyproheptadine
    Sovner, R
  • Antidepressant efficacy of sertraline: a double-blind, placebo-and amitriptyline-controlled, multicenter comparison study in outpatients with major depression
    Reimherr, FW; Chouinard, G; Cohn, CK; Cole, JO; Itil, TM; LaPierre, YD; Masco, HL; Mendels, J
  • Double-blind, multicenter comparison of sertraline and amitriptyline in elderly depressed patients
    Cohn, CK; Shrivastava, R; Mendels, J; Cohn, JB; Fabre, LR; Claghorn, JL; Dessain, EC; Itil, TM; Lautin, A
  • Sertraline: a new antidepressant
    Doogan, DP; Caillard, V
  • Nefazodone versus sertraline in outpatients with major depression: focus on efficacy, tolerability, and effects on sexual function and satisfaction
    Feiger, A; Kiev, A; Shrivastava, RK; Wisselink, PG; Wilcox, CS
  • Psychotropic medications and their effects on sexual function: diagnosis, biology, and treatment approaches
    Gitlin, MJ
  • Double-blind comparison of bupropion sustained release and sertraline in depressed outpatients
    Kavoussi, RJ; Segraves, RT; Hughes, AR; Ascher, JA; Johnston, JA
  • A multicenter evaluation of the efficacy and safety of 150 and 300 mg/d sustained-release bupropion tablets versus placebo in depressed outpatients
    Reimherr, FW; Cunningham, LA; Batey, SR; Johnston, JA; Ascher, JA
  • Bupropion: a review of its mechanism of antidepressant activity
    Ascher, JA; Cole, JO; Colin, J; Feighner, JP; Ferris, RM; Fibiger, HC; Golden, RN; Martin, P; Potter, WZ; Richelson, E; Sulser, F
  • Mechanism of antidepressant activity of bupropion
    Ferris, RM; Cooper, BR
  • Bupropion: an antidepressant without sexual pathophysiological action
    Gardner, EA; Johnston, JA
  • Comparative sexual side effects of bupropion, fluoxetine, paroxetine, and sertraline
    Modell, JG; Katholi, CR; Modell, JD; DePalma, RL
  • A placebo-controlled comparison of the antidepressant and sexual functioning effects of bupropion sustained release and sertraline
    Croft, H; Settle, E; Houser, T; Batey, SR; Donahue, RMJ; Ascher, JA
  • Diagnostic and Statistical Manual of Mental Disorders
  • A rating scale for depression
    Hamilton, M
  • Development of a rating scale for primary depressive illness
    Hamilton, M
  • The effects of steroidal contraceptives on the well-being and sexuality of women: a double-blind, placebo-controlled, two-centre study of combined and progestogen-only methods
    Graham, CA; Ramos, R; Bancroft, J; Maglaya, C; Farley, TMM
  • ECDEU Assessment Manual for Psychopharmacology
    Guy, W
  • Management of depression in the outpatient office
    Salazar, WH
  • Minimizing and managing antidepressant side effects
    McElroy, SL; Keck, PE; Friedman, LM
  • A model for the assessment of sexual dysfunction etiology
    Wise, TN
  • Sertraline safety and efficacy in major depression: a double-blind fixed dose comparison with placebo
    Fabre, LF; Abuzzahab, FS; Amin, M; Claghorn, JL; Mendels, J; Petrie, WM; Dube, S; Small, JG
  • Male sexual side effects associated with antidepressants: a descriptive clinical study of 32 patients
    Hsu, JH; Shen, WW
  • Clinical implications of antidepressant drug effects on sexual function
    Harvey, KV; Balon, R
  • Sertraline: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depression and obsessive-compulsive disorder
    Murdoch, D; McTavish, D
  • Drug holidays to counter sexual dysfunction
    Balon, R
  • Selective serotonin reuptake inhibitor-induced sexual dysfunction: efficacy of a drug holiday
    Rothschild, AJ
  • Discontinuation symptoms following treatment with serotonin reuptake inhibitors; a literature review
    Zajecka, J; Tracy, K; Mitchell, S