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Sexually Dimorphic Effects of Early-Life Exposures to Endocrine Disruptors: Sex-Specific Epigenetic Reprogramming as a Potential Mechanism

Sexually Dimorphic Effects of Early-Life Exposures to Endocrine Disruptors: Sex-Specific... Curr Envir Health Rpt (2017) 4:426–438 DOI 10.1007/s40572-017-0170-z SYNTHETIC CHEMICALS AND HEALTH (J HERBSTMAN AND T JAMES-TODD, SECTION EDITORS) Sexually Dimorphic Effects of Early-Life Exposures to Endocrine Disruptors: Sex-Specific Epigenetic Reprogramming as a Potential Mechanism 1 1 2 2 Carolyn McCabe & Olivia S. Anderson & Luke Montrose & Kari Neier & 1,2 Dana C. Dolinoy Published online: 4 October 2017 Springer International Publishing AG, part of Springer Nature 2017 . . . Abstract Keywords Lead (Pb) Bisphenol A (BPA) Epigenetics Purpose of Review The genetic material of every organism Sexually dimorphic effects Developmental origins of health exists within the context of regulatory networks that govern and disease (DOHaD) gene expression—collectively called the epigenome. Animal models and human birth cohort studies have revealed key developmental periods that are important for epigenetic pro- Introduction gramming and vulnerable to environmental insults. Thus, epi- genetics represent a potential mechanism through which sex- Findings from landmark longitudinal birth cohort studies ually dimorphic effects of early-life exposures such as (e.g., Dutch Hunger Studies) have led scientists to postulate endocrine-disrupting chemicals (EDCs) manifest. that there are key developmental periods important for Recent Findings Several animal studies, and to a lesser extent exposure-related impacts—some of which http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Environmental Health Reports Springer Journals

Sexually Dimorphic Effects of Early-Life Exposures to Endocrine Disruptors: Sex-Specific Epigenetic Reprogramming as a Potential Mechanism

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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer International Publishing AG
Subject
Biomedicine; Pharmacology/Toxicology; Medicine/Public Health, general; Environmental Health
eISSN
2196-5412
DOI
10.1007/s40572-017-0170-z
pmid
28980159
Publisher site
See Article on Publisher Site

Abstract

Curr Envir Health Rpt (2017) 4:426–438 DOI 10.1007/s40572-017-0170-z SYNTHETIC CHEMICALS AND HEALTH (J HERBSTMAN AND T JAMES-TODD, SECTION EDITORS) Sexually Dimorphic Effects of Early-Life Exposures to Endocrine Disruptors: Sex-Specific Epigenetic Reprogramming as a Potential Mechanism 1 1 2 2 Carolyn McCabe & Olivia S. Anderson & Luke Montrose & Kari Neier & 1,2 Dana C. Dolinoy Published online: 4 October 2017 Springer International Publishing AG, part of Springer Nature 2017 . . . Abstract Keywords Lead (Pb) Bisphenol A (BPA) Epigenetics Purpose of Review The genetic material of every organism Sexually dimorphic effects Developmental origins of health exists within the context of regulatory networks that govern and disease (DOHaD) gene expression—collectively called the epigenome. Animal models and human birth cohort studies have revealed key developmental periods that are important for epigenetic pro- Introduction gramming and vulnerable to environmental insults. Thus, epi- genetics represent a potential mechanism through which sex- Findings from landmark longitudinal birth cohort studies ually dimorphic effects of early-life exposures such as (e.g., Dutch Hunger Studies) have led scientists to postulate endocrine-disrupting chemicals (EDCs) manifest. that there are key developmental periods important for Recent Findings Several animal studies, and to a lesser extent exposure-related impacts—some of which

Journal

Current Environmental Health Reports – Springer Journals

Published: Oct 4, 2017

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