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Signaling pathways mediating adhesion and spreading through extracellular ADP and the P2Y12 receptor

Signaling pathways mediating adhesion and spreading through extracellular ADP and the P2Y12 receptor Purinergic Signalling (2013) 9:131–133 DOI 10.1007/s11302-013-9363-6 HIGHLIGHTS IN PURINERGIC SIGNALLING Signaling pathways mediating adhesion and spreading through extracellular ADP and the P2Y receptor Presented by Maria P. Abbracchio Babette Fuss Published online: 28 April 2013 Springer Science+Business Media Dordrecht 2013 Introductory note by the Associate Editor Article summary In this Purinergic Signalling issue, Babette Fuss of the S.-H. Lee and colleagues described in this manuscript a novel Virginia Commonwealth University at Richmond discusses ADP–P2Y receptor signaling cascade that is involved in two interesting papers dealing with P2Y receptor regula- regulating the turnover of focal adhesions, multi-molecular tion of cell adhesion in two different cell types: microglia complexes known to control cell shape and adhesion in (the Glia article) and osteoclasts (the J Clin Invest article). In response to environmental signals [1], and thereby the chemo- Highlight no. 1, new information on the effects mediated by taxis of microglia cells. More specifically, the authors investi- P2Y on microglial function are discussed, with special gated signaling events in microglia cellsthatleadtoERK1/2 focus on the involvement of the ERK–β-arrestin cascade activation upon ADP–P2Y receptor stimulation, and they and on the interactions between ADP-dependent and ADP- analyzed the regulatory roles of ADP–P2Y receptor- independent http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Purinergic Signalling Springer Journals

Signaling pathways mediating adhesion and spreading through extracellular ADP and the P2Y12 receptor

Fuss, Babette
Purinergic Signalling , Volume 9 (2) – Apr 28, 2013
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References (10)

Publisher
Springer Journals
Copyright
Copyright © 2013 by Springer Science+Business Media Dordrecht
Subject
Biomedicine; Biomedicine general; Pharmacology/Toxicology; Human Physiology; Neurosciences; Cancer Research
ISSN
1573-9538
eISSN
1573-9546
DOI
10.1007/s11302-013-9363-6
pmid
23624893
Publisher site
See Article on Publisher Site

Abstract

Purinergic Signalling (2013) 9:131–133 DOI 10.1007/s11302-013-9363-6 HIGHLIGHTS IN PURINERGIC SIGNALLING Signaling pathways mediating adhesion and spreading through extracellular ADP and the P2Y receptor Presented by Maria P. Abbracchio Babette Fuss Published online: 28 April 2013 Springer Science+Business Media Dordrecht 2013 Introductory note by the Associate Editor Article summary In this Purinergic Signalling issue, Babette Fuss of the S.-H. Lee and colleagues described in this manuscript a novel Virginia Commonwealth University at Richmond discusses ADP–P2Y receptor signaling cascade that is involved in two interesting papers dealing with P2Y receptor regula- regulating the turnover of focal adhesions, multi-molecular tion of cell adhesion in two different cell types: microglia complexes known to control cell shape and adhesion in (the Glia article) and osteoclasts (the J Clin Invest article). In response to environmental signals [1], and thereby the chemo- Highlight no. 1, new information on the effects mediated by taxis of microglia cells. More specifically, the authors investi- P2Y on microglial function are discussed, with special gated signaling events in microglia cellsthatleadtoERK1/2 focus on the involvement of the ERK–β-arrestin cascade activation upon ADP–P2Y receptor stimulation, and they and on the interactions between ADP-dependent and ADP- analyzed the regulatory roles of ADP–P2Y receptor- independent

Journal

Purinergic Signalling – Springer Journals

Published: Apr 28, 2013

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