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Somatic mutations

Somatic mutations Nature Vol. 273 8 June 1978 news and views F. Cramer SoMATIC mutations in eukaryotic cells a major portion of the Cn3 domain deleted. In IFl a 'nonsense' mutation have been invoked as the source of 14"/ occurs at amino acid residue 358, antibody diversity, the underlying resulting in early termination. In IF3 cause of cancerous changes, and of the a two-base deletion at residue 341 changes that occur during ageing. 361 causes a frameshift resulting in an However, relatively little is known at aberrant sequence continuing to resi­ the molecular level about the type ami due 354 at which a premature 'ochre' origin of mutations in mammalian termination codon occurs. It is in­ cells, compared with bacteria. teresting that two of the four spon­ One of the most intensively studied taneous mutants have errors arising systems is that of the clonal variants within a 20-residue region between the of the mouse myeloma MOPC-21 cell Cui and Cu3 domains. IF2 is an in­ line, in which C. Milstein and his col­ tracistronic deletion and occurs at the leagues have characterised a series of C- V junction deleting Cnl. The spontaneously arising variants of the mRNA for IF2 gamma-chain is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Somatic mutations

Nature , Volume 273 (5662) – Jun 1, 1978

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Publisher
Springer Journals
Copyright
Copyright © 1978 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/273423a0
Publisher site
See Article on Publisher Site

Abstract

Nature Vol. 273 8 June 1978 news and views F. Cramer SoMATIC mutations in eukaryotic cells a major portion of the Cn3 domain deleted. In IFl a 'nonsense' mutation have been invoked as the source of 14"/ occurs at amino acid residue 358, antibody diversity, the underlying resulting in early termination. In IF3 cause of cancerous changes, and of the a two-base deletion at residue 341 changes that occur during ageing. 361 causes a frameshift resulting in an However, relatively little is known at aberrant sequence continuing to resi­ the molecular level about the type ami due 354 at which a premature 'ochre' origin of mutations in mammalian termination codon occurs. It is in­ cells, compared with bacteria. teresting that two of the four spon­ One of the most intensively studied taneous mutants have errors arising systems is that of the clonal variants within a 20-residue region between the of the mouse myeloma MOPC-21 cell Cui and Cu3 domains. IF2 is an in­ line, in which C. Milstein and his col­ tracistronic deletion and occurs at the leagues have characterised a series of C- V junction deleting Cnl. The spontaneously arising variants of the mRNA for IF2 gamma-chain is

Journal

NatureSpringer Journals

Published: Jun 1, 1978

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