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Statistical Genetics of Quantitative TraitsLinkage Analysis and Map Construction

Statistical Genetics of Quantitative Traits: Linkage Analysis and Map Construction [Linkage is the tendency for genes to be inherited together because they are located near one another on the same chromosome. Linkage analysis of markers lays a foundation for the construction of a genetic linkage map and the subsequent molecular dissection of quantitative traits using the map. Linkage analysis is based on the cosegregation of adjacent markers and their cotransmission to the next progeny generation. The prerequisite of linkage analysis between any two markers is their known allelic arrangements (i.e., linkage phases) on the homologous chromosome so that parental (or nonrecombinant) vs. nonparental (or recombinant) haplotypes can be readily distinguished. In many domesticated plants and animals, phase-known mapping pedigrees can be established using a segregating population, such as the backcross or F2, derived from two homologous inbred lines. (Recall the definitions in Section 1.5.) Theories for linkage analysis in such segregating pedigrees have been well-developed.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Statistical Genetics of Quantitative TraitsLinkage Analysis and Map Construction

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Publisher
Springer New York
Copyright
© Springer Science + Business Media, LLC 2007
ISBN
978-0-387-20334-8
Pages
43 –75
DOI
10.1007/978-0-387-68154-2_3
Publisher site
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Abstract

[Linkage is the tendency for genes to be inherited together because they are located near one another on the same chromosome. Linkage analysis of markers lays a foundation for the construction of a genetic linkage map and the subsequent molecular dissection of quantitative traits using the map. Linkage analysis is based on the cosegregation of adjacent markers and their cotransmission to the next progeny generation. The prerequisite of linkage analysis between any two markers is their known allelic arrangements (i.e., linkage phases) on the homologous chromosome so that parental (or nonrecombinant) vs. nonparental (or recombinant) haplotypes can be readily distinguished. In many domesticated plants and animals, phase-known mapping pedigrees can be established using a segregating population, such as the backcross or F2, derived from two homologous inbred lines. (Recall the definitions in Section 1.5.) Theories for linkage analysis in such segregating pedigrees have been well-developed.]

Published: Jan 1, 2007

Keywords: Linkage Analysis; Doubled Haploid; Doubled Haploid Population; Recombination Fraction; Marker Pair

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