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Statistical Genetics of Quantitative TraitsThe Structure of QTL Mapping

Statistical Genetics of Quantitative Traits: The Structure of QTL Mapping [In the previous chapter, statistical approaches were described for evaluating associations between markers and phenotypes. Such an association analysis can provide evidence for the genetic control of trait variation but is not very precise because the genetic effects associated with marker genotypes are confounded by the position of a functional QTL and its actual effect. Of course, if markers are so highly dense that they are generated at QTL positions, a simple marker-phenotype association analysis may be useful. The generation of such high-density maps is not possible for a majority of species in practice. Powerful analytical techniques are needed to separate the effects of a QTL from its location.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Statistical Genetics of Quantitative TraitsThe Structure of QTL Mapping

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Publisher
Springer New York
Copyright
© Springer Science + Business Media, LLC 2007
ISBN
978-0-387-20334-8
Pages
203 –221
DOI
10.1007/978-0-387-68154-2_9
Publisher site
See Chapter on Publisher Site

Abstract

[In the previous chapter, statistical approaches were described for evaluating associations between markers and phenotypes. Such an association analysis can provide evidence for the genetic control of trait variation but is not very precise because the genetic effects associated with marker genotypes are confounded by the position of a functional QTL and its actual effect. Of course, if markers are so highly dense that they are generated at QTL positions, a simple marker-phenotype association analysis may be useful. The generation of such high-density maps is not possible for a majority of species in practice. Powerful analytical techniques are needed to separate the effects of a QTL from its location.]

Published: Jan 1, 2007

Keywords: Mixture Model; Posterior Distribution; Markov Chain Monte Carlo; Marker Genotype; Likelihood Equation

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