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Statistical Genetics of Quantitative TraitsThreshold and Precision Analysis

Statistical Genetics of Quantitative Traits: Threshold and Precision Analysis [In the preceding chapter, we described the basic principle for interval mapping of QTLs within the maximum likelihood context, but two fundamental questions should be addressed toward the QTL analysis of complex traits. First, what is the critical threshold of the test statistic that can be used to declare the statistical significance of a QTL? Second, after the significant QTL is determined, how are the estimates of likelihoods and QTL parameters adequately precise to make a scientific inference about QTL position and effect? Statistically, these two questions present different aspects of QTL mapping, but we will describe them here in a single chapter as two important follow-ups of QTL mapping.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Statistical Genetics of Quantitative TraitsThreshold and Precision Analysis

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Publisher
Springer New York
Copyright
© Springer Science + Business Media, LLC 2007
ISBN
978-0-387-20334-8
Pages
269 –285
DOI
10.1007/978-0-387-68154-2_12
Publisher site
See Chapter on Publisher Site

Abstract

[In the preceding chapter, we described the basic principle for interval mapping of QTLs within the maximum likelihood context, but two fundamental questions should be addressed toward the QTL analysis of complex traits. First, what is the critical threshold of the test statistic that can be used to declare the statistical significance of a QTL? Second, after the significant QTL is determined, how are the estimates of likelihoods and QTL parameters adequately precise to make a scientific inference about QTL position and effect? Statistically, these two questions present different aspects of QTL mapping, but we will describe them here in a single chapter as two important follow-ups of QTL mapping.]

Published: Jan 1, 2007

Keywords: Doubled Haploid; Nuisance Parameter; Doubled Haploid Population; Marker Interval; Threshold Determination

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