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Tardive Dyskinesia and Ethnicity: Review of theLiterature

Tardive Dyskinesia and Ethnicity: Review of theLiterature Annals of Clinical Psychiatry, Vol 9, No. 1, 1997 Tardive Dyskinesia and Ethnicity: Review of the Literature J. Randolph Swartz, M.D.,1,2 Karl Burgoyne, M.D.,1 Michael Smith, M.D.,1 Rangaswamy Gadasally, M.D.,1 Jambur Ananth, M.D., and Kartik Ananth, B.S. Tardive dyskinesia (TD) is a side effect of long-term neuroleptic administration. The wide variation of 2 to 51% in its reported prevalence can be attributed to the varied definitions of TD, the use of different methods of assessment, and the lack of control of independent variables. Why only certain patients develop this side effect is an intriguing question. The occurrence of TD in family members and in those persons with a family history of Parkinson's disease (PD) is suggestive of genetic vulnerability. Further support for a genetic predispo- sition comes from the fact that only certain strains of monkeys, such as the Cebus apella strain, have a higher propensity to develop TD than others, such as the Macaca sepciosa strain. If genetic factors play a significant role in the development of TD, then, genetically diverse ethnic groups may have a different propensity for the development of TD. One method of evaluating such a possibility is to compare its prevalence in different countries. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Clinical Psychiatry Springer Journals

Tardive Dyskinesia and Ethnicity: Review of theLiterature

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References (68)

Publisher
Springer Journals
Copyright
Copyright © 1997 by American Academy of Clinical Psychiatrists
Subject
Medicine & Public Health; Neurology; Psychiatry; Psychopharmacology
ISSN
1040-1237
eISSN
1573-3238
DOI
10.1023/A:1026282325507
Publisher site
See Article on Publisher Site

Abstract

Annals of Clinical Psychiatry, Vol 9, No. 1, 1997 Tardive Dyskinesia and Ethnicity: Review of the Literature J. Randolph Swartz, M.D.,1,2 Karl Burgoyne, M.D.,1 Michael Smith, M.D.,1 Rangaswamy Gadasally, M.D.,1 Jambur Ananth, M.D., and Kartik Ananth, B.S. Tardive dyskinesia (TD) is a side effect of long-term neuroleptic administration. The wide variation of 2 to 51% in its reported prevalence can be attributed to the varied definitions of TD, the use of different methods of assessment, and the lack of control of independent variables. Why only certain patients develop this side effect is an intriguing question. The occurrence of TD in family members and in those persons with a family history of Parkinson's disease (PD) is suggestive of genetic vulnerability. Further support for a genetic predispo- sition comes from the fact that only certain strains of monkeys, such as the Cebus apella strain, have a higher propensity to develop TD than others, such as the Macaca sepciosa strain. If genetic factors play a significant role in the development of TD, then, genetically diverse ethnic groups may have a different propensity for the development of TD. One method of evaluating such a possibility is to compare its prevalence in different countries.

Journal

Annals of Clinical Psychiatry – Springer Journals

Published: Sep 20, 2004

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