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The biodiversity hypothesis and immunotolerance in allergy

The biodiversity hypothesis and immunotolerance in allergy review Allergo J Int (2018) 27:140–146 https://doi.org/10.1007/s40629-018-0072-0 Susanne Kaesler · Yuliya Skabytska · Thomas Volz · Tilo Biedermann Received: 23 November 2017 / Accepted: 12 March 2018 / Published online: 12 June 2018 © Springer Medizin Verlag GmbH, a part of Springer Nature 2018 Abstract Keywords Immunotolerance · Treg · Biodiversity · Background The human immune system is capable Microbiome · Cutaneous sensitization of detecting a multitude of substances and organisms Abbreviations in the environment and responding to these in a va- DC Dendritic cells riety of ways. This includes immune responses to IgE Immunoglobulin E pathogens, on the one hand, and immunotolerance IL Interleukin in the form of immunoregulatory responses, resulting iTreg “Induced” regulatory T cells in either the termination of immune responses or in MHC Major histocompatibility complex tolerance to harmless and endogenous substances, on nTreg “Natural” regulatory T cells the other. The development of immunotolerance is an SCORAD Score of Atopic Dermatitis active process that is essentially characterized by in- Th cells T helper cell subtypes teraction with microbiota and environmental compo- Treg Regulatory T cells nents and is primarily mediated by regulatory T cells. Methods This article provides an overview of selected scientific articles and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Allergo Journal International Springer Journals

The biodiversity hypothesis and immunotolerance in allergy

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Medizin Verlag GmbH, a part of Springer Nature
Subject
Medicine & Public Health; Allergology; Dermatology; Environmental Health; Immunology
eISSN
2197-0378
DOI
10.1007/s40629-018-0072-0
Publisher site
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Abstract

review Allergo J Int (2018) 27:140–146 https://doi.org/10.1007/s40629-018-0072-0 Susanne Kaesler · Yuliya Skabytska · Thomas Volz · Tilo Biedermann Received: 23 November 2017 / Accepted: 12 March 2018 / Published online: 12 June 2018 © Springer Medizin Verlag GmbH, a part of Springer Nature 2018 Abstract Keywords Immunotolerance · Treg · Biodiversity · Background The human immune system is capable Microbiome · Cutaneous sensitization of detecting a multitude of substances and organisms Abbreviations in the environment and responding to these in a va- DC Dendritic cells riety of ways. This includes immune responses to IgE Immunoglobulin E pathogens, on the one hand, and immunotolerance IL Interleukin in the form of immunoregulatory responses, resulting iTreg “Induced” regulatory T cells in either the termination of immune responses or in MHC Major histocompatibility complex tolerance to harmless and endogenous substances, on nTreg “Natural” regulatory T cells the other. The development of immunotolerance is an SCORAD Score of Atopic Dermatitis active process that is essentially characterized by in- Th cells T helper cell subtypes teraction with microbiota and environmental compo- Treg Regulatory T cells nents and is primarily mediated by regulatory T cells. Methods This article provides an overview of selected scientific articles and

Journal

Allergo Journal International – Springer Journals

Published: Jun 12, 2018

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