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The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers

The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and... Clin Pharmacokinet (2016) 55:495–506 DOI 10.1007/s40262-015-0332-9 ORIGINAL RESEARCH ARTICLE The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers 1,3 1,4 1,5 1 • • • • Kari M. Morrissey Sophie L. Stocker Eugene C. Chen Richard A. Castro 2 1 Claire M. Brett Kathleen M. Giacomini Published online: 27 October 2015 Springer International Publishing Switzerland 2015 Abstract and pharmacodynamics of basic drugs, such as metformin, Background and Objectives In the proximal tubule, basic is unknown. This study sought to identify a selective drugs are transported from the renal cells to the tubule MATE2K inhibitor in vitro and to determine its clinical lumen through the concerted action of the H /organic impact on the pharmacokinetics and pharmacodynamics of cation antiporters, multidrug and toxin extrusion (MATE) 1 metformin in healthy subjects. and MATE2K. Dual inhibitors of the MATE transporters Methods Strategic cell-based screening of 71 US Food have been shown to have a clinically relevant effect on the and Drug Administration (FDA)-approved medications pharmacokinetics of concomitantly administered basic was conducted to identify selective inhibitors of renal drugs. However, the clinical impact of selective renal organic cation transporters that are capable of inhibiting http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Pharmacokinetics Springer Journals

The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers

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References (59)

Publisher
Springer Journals
Copyright
Copyright © 2015 by Springer International Publishing Switzerland
Subject
Medicine & Public Health; Pharmacotherapy; Pharmacology/Toxicology; Internal Medicine
ISSN
0312-5963
eISSN
1179-1926
DOI
10.1007/s40262-015-0332-9
pmid
26507723
Publisher site
See Article on Publisher Site

Abstract

Clin Pharmacokinet (2016) 55:495–506 DOI 10.1007/s40262-015-0332-9 ORIGINAL RESEARCH ARTICLE The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers 1,3 1,4 1,5 1 • • • • Kari M. Morrissey Sophie L. Stocker Eugene C. Chen Richard A. Castro 2 1 Claire M. Brett Kathleen M. Giacomini Published online: 27 October 2015 Springer International Publishing Switzerland 2015 Abstract and pharmacodynamics of basic drugs, such as metformin, Background and Objectives In the proximal tubule, basic is unknown. This study sought to identify a selective drugs are transported from the renal cells to the tubule MATE2K inhibitor in vitro and to determine its clinical lumen through the concerted action of the H /organic impact on the pharmacokinetics and pharmacodynamics of cation antiporters, multidrug and toxin extrusion (MATE) 1 metformin in healthy subjects. and MATE2K. Dual inhibitors of the MATE transporters Methods Strategic cell-based screening of 71 US Food have been shown to have a clinically relevant effect on the and Drug Administration (FDA)-approved medications pharmacokinetics of concomitantly administered basic was conducted to identify selective inhibitors of renal drugs. However, the clinical impact of selective renal organic cation transporters that are capable of inhibiting

Journal

Clinical PharmacokineticsSpringer Journals

Published: Oct 27, 2015

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