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The Fourth Birt–Hogg–Dubé Symposium, Cincinnati, USA, 28th–30th March, 2012

The Fourth Birt–Hogg–Dubé Symposium, Cincinnati, USA, 28th–30th March, 2012 Familial Cancer (2013) 12:133–140 DOI 10.1007/s10689-012-9528-4 AB STRACTS The Fourth Birt–Hogg–Dube ´ Symposium, Cincinnati, USA, th th 28 –30 March, 2012 Springer Science+Business Media B.V. 2012 Nephrology and Hypertension, University Medical Center Utrecht, FLCN loss causes hematopoietic stem cell homeostasis Utrecht, 3584 CX, The Netherlands, s.g.basten@umcutrecht.nl; dysregulation and myeloproliferative disease 2 3 University Medical Center Utrecht; Maastricht University Medical Center 1 2 3 Masaya Baba , Hyung-Chan Suh , Hisashi Hasumi , 3 2 3 3 Ciliopathy is a general term applied to diseases that originate from Yukiko Hasumi , Ming Ji , Mara E. Klein , Laura S. Schmidt , 3 2 ciliary dysfunction, which often coincide with renal cyst develop- W. Marston Linehan , Jonathan R. Keller ment. Birt-Hogg-Dube (BHD) syndrome was therefore suspected as a Staff Scientist, Urologic Oncology Branch, National Cancer novel ciliopathy. Indeed, folliculin (FLCN), the BHD gene product, Institute, NIH, Bethesda, MD, 20892, United States, localizes to primary cilia. To study ciliopathies in detail, we set up a babam@mail.nih.gov; National Cancer Institute-Frederick, NIH; renal 3D culture system that physiologically mimic polarized renal National Cancer Institute, NIH tubuli. Upon SiFlcn in this system, several affected processes were identified; (1) Reduction of ciliation in vitro http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Familial Cancer Springer Journals

The Fourth Birt–Hogg–Dubé Symposium, Cincinnati, USA, 28th–30th March, 2012

Familial Cancer , Volume 12 (1) – Mar 1, 2013

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References (40)

Publisher
Springer Journals
Copyright
Copyright © Springer Science+Business Media B.V. 2012
Subject
Biomedicine; Cancer Research; Human Genetics; Epidemiology; Biomedicine general
ISSN
1389-9600
eISSN
1573-7292
DOI
10.1007/s10689-012-9528-4
Publisher site
See Article on Publisher Site

Abstract

Familial Cancer (2013) 12:133–140 DOI 10.1007/s10689-012-9528-4 AB STRACTS The Fourth Birt–Hogg–Dube ´ Symposium, Cincinnati, USA, th th 28 –30 March, 2012 Springer Science+Business Media B.V. 2012 Nephrology and Hypertension, University Medical Center Utrecht, FLCN loss causes hematopoietic stem cell homeostasis Utrecht, 3584 CX, The Netherlands, s.g.basten@umcutrecht.nl; dysregulation and myeloproliferative disease 2 3 University Medical Center Utrecht; Maastricht University Medical Center 1 2 3 Masaya Baba , Hyung-Chan Suh , Hisashi Hasumi , 3 2 3 3 Ciliopathy is a general term applied to diseases that originate from Yukiko Hasumi , Ming Ji , Mara E. Klein , Laura S. Schmidt , 3 2 ciliary dysfunction, which often coincide with renal cyst develop- W. Marston Linehan , Jonathan R. Keller ment. Birt-Hogg-Dube (BHD) syndrome was therefore suspected as a Staff Scientist, Urologic Oncology Branch, National Cancer novel ciliopathy. Indeed, folliculin (FLCN), the BHD gene product, Institute, NIH, Bethesda, MD, 20892, United States, localizes to primary cilia. To study ciliopathies in detail, we set up a babam@mail.nih.gov; National Cancer Institute-Frederick, NIH; renal 3D culture system that physiologically mimic polarized renal National Cancer Institute, NIH tubuli. Upon SiFlcn in this system, several affected processes were identified; (1) Reduction of ciliation in vitro

Journal

Familial CancerSpringer Journals

Published: Mar 1, 2013

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