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The involvement of astrocytes and kynurenine pathway in Alzheimer’s disease

The involvement of astrocytes and kynurenine pathway in Alzheimer’s disease The kynurenine pathway (KP) and several of its neuroactive products, especially quinolinic acid (QUIN), are considered to be involved in the neuropathogenesis of Alzheimer’s disease (AD). There is growing evidence suggesting that astrocytes play a critical role in the regulation of the excitotoxicity and inflammatory processes that occur during the evolution of AD. This review focuses on the role of astrocytes through their relation with the KP to the different features associated with AD including cytokine, chemokine and, adhesion molecule production, cytoskeletal changes, astrogliosis, excitotoxicity, apoptosis and neurodegeneration. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurotoxicity Research Springer Journals

The involvement of astrocytes and kynurenine pathway in Alzheimer’s disease

Neurotoxicity Research , Volume 12 (4) – Mar 6, 2009

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References (160)

Publisher
Springer Journals
Copyright
Copyright © 2007 by Springer
Subject
Biomedicine; Neurosciences; Pharmaceutical Sciences/Technology; Neurology; Neurochemistry; Pharmacology/Toxicology; Neurobiology
ISSN
1029-8428
eISSN
1476-3524
DOI
10.1007/BF03033908
Publisher site
See Article on Publisher Site

Abstract

The kynurenine pathway (KP) and several of its neuroactive products, especially quinolinic acid (QUIN), are considered to be involved in the neuropathogenesis of Alzheimer’s disease (AD). There is growing evidence suggesting that astrocytes play a critical role in the regulation of the excitotoxicity and inflammatory processes that occur during the evolution of AD. This review focuses on the role of astrocytes through their relation with the KP to the different features associated with AD including cytokine, chemokine and, adhesion molecule production, cytoskeletal changes, astrogliosis, excitotoxicity, apoptosis and neurodegeneration.

Journal

Neurotoxicity ResearchSpringer Journals

Published: Mar 6, 2009

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