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The microbiome and innate immunity

The microbiome and innate immunity The intestinal microbiome is a signalling hub that integrates environmental inputs, such as diet, with genetic and immune signals to affect the host's metabolism, immunity and response to infection. The haematopoietic and non-haematopoietic cells of the innate immune system are located strategically at the host–microbiome interface. These cells have the ability to sense microorganisms or their metabolic products and to translate the signals into host physiological responses and the regulation of microbial ecology. Aberrations in the communication between the innate immune system and the gut microbiota might contribute to complex diseases. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

The microbiome and innate immunity

Nature , Volume 535 (7610) – Jul 6, 2016

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References (166)

Publisher
Springer Journals
Copyright
Copyright © 2016 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/nature18847
Publisher site
See Article on Publisher Site

Abstract

The intestinal microbiome is a signalling hub that integrates environmental inputs, such as diet, with genetic and immune signals to affect the host's metabolism, immunity and response to infection. The haematopoietic and non-haematopoietic cells of the innate immune system are located strategically at the host–microbiome interface. These cells have the ability to sense microorganisms or their metabolic products and to translate the signals into host physiological responses and the regulation of microbial ecology. Aberrations in the communication between the innate immune system and the gut microbiota might contribute to complex diseases.

Journal

NatureSpringer Journals

Published: Jul 6, 2016

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