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The multifactorial role of neutrophils in rheumatoid arthritis

The multifactorial role of neutrophils in rheumatoid arthritis Neutrophils contribute to rheumatoid arthritis (RA) pathology through the release of cytotoxic and immunoregulatory molecules Neutrophils from patients with RA have an activated phenotype: delayed apoptosis, increased capacity to produce reactive oxygen species, active gene expression and membrane expression of high-affinity Fcγ receptors In mouse models of RA, neutrophils are critical to initiation and progression of the disease Neutrophil extracellular traps might be a source of citrullinated autoantigens (hypercitrullinated cytoplasmic proteins and citrullinated histones) in RA Anticitrullinated protein antibodies are a hallmark of RA, and high titres of such autoantibodies are associated with severe disease http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Reviews Rheumatology Springer Journals

The multifactorial role of neutrophils in rheumatoid arthritis

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References (104)

Publisher
Springer Journals
Copyright
Copyright © 2014 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Subject
Medicine & Public Health; Medicine/Public Health, general; Rheumatology
ISSN
1759-4790
eISSN
1759-4804
DOI
10.1038/nrrheum.2014.80
Publisher site
See Article on Publisher Site

Abstract

Neutrophils contribute to rheumatoid arthritis (RA) pathology through the release of cytotoxic and immunoregulatory molecules Neutrophils from patients with RA have an activated phenotype: delayed apoptosis, increased capacity to produce reactive oxygen species, active gene expression and membrane expression of high-affinity Fcγ receptors In mouse models of RA, neutrophils are critical to initiation and progression of the disease Neutrophil extracellular traps might be a source of citrullinated autoantigens (hypercitrullinated cytoplasmic proteins and citrullinated histones) in RA Anticitrullinated protein antibodies are a hallmark of RA, and high titres of such autoantibodies are associated with severe disease

Journal

Nature Reviews RheumatologySpringer Journals

Published: Jun 10, 2014

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