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The relationship between obesity and bone mineral density in children and adolescents: analysis of the National Health and Nutrition Examination Survey

The relationship between obesity and bone mineral density in children and adolescents: analysis... SummaryChildhood and puberty are important period for the skeleton grows. Fat mass, especially visceral adipose tissue, was negatively correlated with areal bone mineral density in children and adolescents. The present study suggests that fat mass, especially visceral adipose tissue, has a slightly negative association with bone development in children and adolescents.PurposeThis study observed the relationship between fat mass and distribution, and areal bone mineral density (aBMD) in children and adolescents.MethodsA retrospective study was conducted on US children and adolescents aged 8–19 years. Whole body (less head) aBMD was evaluated. Height (Ht) adjusted Z-scores for aBMD were calculated.ResultsAfter controlling for age, gender, race, and lean body mass index (LBMI) Z-score, there were significant negative associations between fat mass index (FMI) Z-score and aBMD Ht-Z-adjusted Z-score (β =  − 0.272, P < 0.001, R2 = 0.033). In the linear regression models with aBMD Ht-Z-adjusted Z-score as the dependent variable, the regression coefficients of android fat mass were − 0.241 (P < 0.05, R2 = 0.002), − 0.473 (P < 0.001, R2 = 0.036), and − 0.474 (P < 0.001, R2 = 0.038) for healthy weight, overweight, and obesity group, respectively. The regression coefficients of visceral adipose tissue (VAT) mass were − 0.218 (P > 0.05, R2 = 0.001), − 2.025 (P < 0.001, R2 = 0.044), and − 1.826 (P < 0.001, R2 = 0.039), and the regression coefficients of subcutaneous adipose tissue (SAT) mass were − 0.467 (P < 0.001, R2 = 0.004), − 0.339 (P < 0.01, R2 = 0.024), and − 0.347 (P < 0.001, R2 = 0.018) for healthy weight, overweight, and obesity group, respectively.ConclusionsThe present study suggests that fat mass has a slightly negative association with bone development in children and adolescents. Trunk fat accumulation, especially visceral adipose tissue, was correlated with the lower level of aBMD. This association was obvious in overweight and obese children. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Osteoporosis Springer Journals

The relationship between obesity and bone mineral density in children and adolescents: analysis of the National Health and Nutrition Examination Survey

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Publisher
Springer Journals
Copyright
Copyright © International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
ISSN
1862-3522
eISSN
1862-3514
DOI
10.1007/s11657-022-01208-4
Publisher site
See Article on Publisher Site

Abstract

SummaryChildhood and puberty are important period for the skeleton grows. Fat mass, especially visceral adipose tissue, was negatively correlated with areal bone mineral density in children and adolescents. The present study suggests that fat mass, especially visceral adipose tissue, has a slightly negative association with bone development in children and adolescents.PurposeThis study observed the relationship between fat mass and distribution, and areal bone mineral density (aBMD) in children and adolescents.MethodsA retrospective study was conducted on US children and adolescents aged 8–19 years. Whole body (less head) aBMD was evaluated. Height (Ht) adjusted Z-scores for aBMD were calculated.ResultsAfter controlling for age, gender, race, and lean body mass index (LBMI) Z-score, there were significant negative associations between fat mass index (FMI) Z-score and aBMD Ht-Z-adjusted Z-score (β =  − 0.272, P < 0.001, R2 = 0.033). In the linear regression models with aBMD Ht-Z-adjusted Z-score as the dependent variable, the regression coefficients of android fat mass were − 0.241 (P < 0.05, R2 = 0.002), − 0.473 (P < 0.001, R2 = 0.036), and − 0.474 (P < 0.001, R2 = 0.038) for healthy weight, overweight, and obesity group, respectively. The regression coefficients of visceral adipose tissue (VAT) mass were − 0.218 (P > 0.05, R2 = 0.001), − 2.025 (P < 0.001, R2 = 0.044), and − 1.826 (P < 0.001, R2 = 0.039), and the regression coefficients of subcutaneous adipose tissue (SAT) mass were − 0.467 (P < 0.001, R2 = 0.004), − 0.339 (P < 0.01, R2 = 0.024), and − 0.347 (P < 0.001, R2 = 0.018) for healthy weight, overweight, and obesity group, respectively.ConclusionsThe present study suggests that fat mass has a slightly negative association with bone development in children and adolescents. Trunk fat accumulation, especially visceral adipose tissue, was correlated with the lower level of aBMD. This association was obvious in overweight and obese children.

Journal

Archives of OsteoporosisSpringer Journals

Published: Jan 23, 2023

Keywords: Obesity; Bone mineral density; Children; Adolescents

References