Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Therapeutic targeting of the hypoxic tumour microenvironment

Therapeutic targeting of the hypoxic tumour microenvironment Hypoxia is prevalent in human tumours and contributes to microenvironments that shape cancer evolution and adversely affect therapeutic outcomes. Historically, two different tumour microenvironment (TME) research communities have been discernible. One has focused on physicochemical gradients of oxygen, pH and nutrients in the tumour interstitium, motivated in part by the barrier that hypoxia poses to effective radiotherapy. The other has focused on cellular interactions involving tumour and non-tumour cells within the TME. Over the past decade, strong links have been established between these two themes, providing new insights into fundamental aspects of tumour biology and presenting new strategies for addressing the effects of hypoxia and other microenvironmental features that arise from the inefficient microvascular system in solid tumours. This Review provides a perspective on advances at the interface between these two aspects of the TME, with a focus on translational therapeutic opportunities relating to the elimination and/or exploitation of tumour hypoxia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Reviews Clinical Oncology Springer Journals

Therapeutic targeting of the hypoxic tumour microenvironment

Loading next page...
 
/lp/springer-journals/therapeutic-targeting-of-the-hypoxic-tumour-microenvironment-RwsKcLQViC

References (313)

Publisher
Springer Journals
Copyright
Copyright © Springer Nature Limited 2021
ISSN
1759-4774
eISSN
1759-4782
DOI
10.1038/s41571-021-00539-4
Publisher site
See Article on Publisher Site

Abstract

Hypoxia is prevalent in human tumours and contributes to microenvironments that shape cancer evolution and adversely affect therapeutic outcomes. Historically, two different tumour microenvironment (TME) research communities have been discernible. One has focused on physicochemical gradients of oxygen, pH and nutrients in the tumour interstitium, motivated in part by the barrier that hypoxia poses to effective radiotherapy. The other has focused on cellular interactions involving tumour and non-tumour cells within the TME. Over the past decade, strong links have been established between these two themes, providing new insights into fundamental aspects of tumour biology and presenting new strategies for addressing the effects of hypoxia and other microenvironmental features that arise from the inefficient microvascular system in solid tumours. This Review provides a perspective on advances at the interface between these two aspects of the TME, with a focus on translational therapeutic opportunities relating to the elimination and/or exploitation of tumour hypoxia.

Journal

Nature Reviews Clinical OncologySpringer Journals

Published: Dec 1, 2021

There are no references for this article.