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TIR enzymatic functions: signaling molecules and receptor mechanisms

TIR enzymatic functions: signaling molecules and receptor mechanisms The evolutionarily conserved Toll/Interleukin-1 Receptor (TIR) domains across kingdoms of prokaryotes, plants, and animals play critical roles in innate immunity. Recent studies have revealed the enzymatic functions of TIRs, the structural bases of TIRs as holoenzymes, and the identity of TIR-generated small signaling molecules and their receptors, which significantly advanced our understanding on TIR-mediated immune signaling pathways. We reviewed the most up-to-date findings in TIR enzymatic functions from the perspectives of signaling molecules and receptor mechanisms. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png aBIOTECH Springer Journals

TIR enzymatic functions: signaling molecules and receptor mechanisms

aBIOTECH , Volume 4 (2) – Jun 1, 2023

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References (46)

Publisher
Springer Journals
Copyright
Copyright © Agricultural Information Institute, Chinese Academy of Agricultural Sciences 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
ISSN
2096-6326
eISSN
2662-1738
DOI
10.1007/s42994-023-00104-w
Publisher site
See Article on Publisher Site

Abstract

The evolutionarily conserved Toll/Interleukin-1 Receptor (TIR) domains across kingdoms of prokaryotes, plants, and animals play critical roles in innate immunity. Recent studies have revealed the enzymatic functions of TIRs, the structural bases of TIRs as holoenzymes, and the identity of TIR-generated small signaling molecules and their receptors, which significantly advanced our understanding on TIR-mediated immune signaling pathways. We reviewed the most up-to-date findings in TIR enzymatic functions from the perspectives of signaling molecules and receptor mechanisms.

Journal

aBIOTECHSpringer Journals

Published: Jun 1, 2023

Keywords: NLR immune receptors; TIR domains; Signaling molecules; Cell death

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