Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Transient focal neurologic deficits upon hematopoietic stem cell transplantation: just a coincidence?

Transient focal neurologic deficits upon hematopoietic stem cell transplantation: just a... Acta Neurol Belg (2019) 119:129–131 https://doi.org/10.1007/s13760-017-0846-z LETTER TO THE EDITOR Transient focal neurologic deficits upon hematopoietic stem cell transplantation: just a coincidence? 1 2 2 Alexandros A. Polymeris  · Gregor T. Stehle  · Michael Medinger  · Gian Marco De Marchis   Received: 23 July 2017 / Accepted: 6 October 2017 / Published online: 17 October 2017 © Belgian Neurological Society 2017 Introduction tongue palsy with dysarthria, and distal right arm paresis. He had a National Institutes of Health Stroke Scale score of The infusion of hematopoietic stem cells cryopreserved seven points. An acute pontine stroke involving the left medial lon- with dimethylsulfoxide (DMSO) has rarely been associated with neurologic adverse events including stroke, seizures, gitudinal fasciculus and the corticobulbar/spinal tracts was postulated. We requested an urgent brain MRI [short stroke and encephalopathy [1]. Here, we report a challenging case of acute transient brainstem dysfunction upon DMSO-cryo- protocol including diffusion-weighted (DWI), susceptibil - ity-weighted (SWI), and fluid-attenuated inversion recovery preserved hematopoietic stem cell transplantation (HSCT). (FLAIR) imaging] to demonstrate the suspected ischemia, deviating from the standard operating procedure, which Case report dictates a faster plain CT prior to considering thromboly- sis. This decision was prompted by the patient’s potentially A 67-year-old man, diagnosed with plasma cell myeloma, increased bleeding risk, due to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Neurologica Belgica Springer Journals

Transient focal neurologic deficits upon hematopoietic stem cell transplantation: just a coincidence?

Download PDF
3 pages

Loading next page...
 
/lp/springer-journals/transient-focal-neurologic-deficits-upon-hematopoietic-stem-cell-7NuCJ00e4I
Publisher
Springer Journals
Copyright
Copyright © 2017 by Belgian Neurological Society
Subject
Biomedicine; Neurosciences; Neurology; Neuroradiology; Medicine/Public Health, general
ISSN
0300-9009
eISSN
2240-2993
DOI
10.1007/s13760-017-0846-z
Publisher site
See Article on Publisher Site

Abstract

Acta Neurol Belg (2019) 119:129–131 https://doi.org/10.1007/s13760-017-0846-z LETTER TO THE EDITOR Transient focal neurologic deficits upon hematopoietic stem cell transplantation: just a coincidence? 1 2 2 Alexandros A. Polymeris  · Gregor T. Stehle  · Michael Medinger  · Gian Marco De Marchis   Received: 23 July 2017 / Accepted: 6 October 2017 / Published online: 17 October 2017 © Belgian Neurological Society 2017 Introduction tongue palsy with dysarthria, and distal right arm paresis. He had a National Institutes of Health Stroke Scale score of The infusion of hematopoietic stem cells cryopreserved seven points. An acute pontine stroke involving the left medial lon- with dimethylsulfoxide (DMSO) has rarely been associated with neurologic adverse events including stroke, seizures, gitudinal fasciculus and the corticobulbar/spinal tracts was postulated. We requested an urgent brain MRI [short stroke and encephalopathy [1]. Here, we report a challenging case of acute transient brainstem dysfunction upon DMSO-cryo- protocol including diffusion-weighted (DWI), susceptibil - ity-weighted (SWI), and fluid-attenuated inversion recovery preserved hematopoietic stem cell transplantation (HSCT). (FLAIR) imaging] to demonstrate the suspected ischemia, deviating from the standard operating procedure, which Case report dictates a faster plain CT prior to considering thromboly- sis. This decision was prompted by the patient’s potentially A 67-year-old man, diagnosed with plasma cell myeloma, increased bleeding risk, due to

Journal

Acta Neurologica Belgica – Springer Journals

Published: Oct 17, 2017

References

  • DMSO-associated encephalopathy during autologous peripheral stem cell infusion: a predisposing role of preconditioning exposure to CNS-penetrating agents?
    Marcacci, G; Corazzelli, G; Becchimanzi, C; Arcamone, M; Capobianco, G; Russo, F; Frigeri, F; Pinto, A
  • Evaluation of a heparin-calibrated antifactor Xa assay for measuring the anticoagulant effect of oral direct Xa inhibitors
    Beyer, J; Trujillo, T; Fisher, S; Ko, A; Lind, SE; Kiser, TH
  • False-negative diffusion-weighted MR findings in acute ischemic stroke
    Oppenheim, C; Stanescu, R; Dormont, D; Crozier, S; Marro, B; Samson, Y; Rancurel, G; Marsault, C
  • Paradoxical embolism after peripheral blood stem cell infusion
    Darabi, K; Brown, JR; Kao, GS
  • Plasma and cerebrospinal fluid pharmacokinetics of thalidomide and lenalidomide in nonhuman primates
    Muscal, JA; Sun, Y; Nuchtern, JG; Dauser, RC; McGuffey, LH; Gibson, BW; Berg, SL
  • Cryopreserved stem cell products containing dimethyl sulfoxide lead to activation of the coagulation system without any impact on engraftment
    Holbro, A; Graf, L; Topalidou, M; Bucher, C; Passweg, JR; Tsakiris, DA