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Trichomonas vaginalis: An Updated Overview Towards Diagnostic Improvement

Trichomonas vaginalis: An Updated Overview Towards Diagnostic Improvement The protozoan Trichomonas vaginalis (TV) is responsible for trichomonosis, a sexually transmitted disease (STD) with a significant incidence worldwide. This infection is one of the most common non-viral STDs, representing almost 50% of all curable STDs. Trichomonosis has an incidence of 180 million new cases worldwide. Nowadays, the ‘gold standard’ for TV diagnosis remains the use of in vitro cultures combined with daily visual microscopic evaluations, which is a time-consuming and low sensitive method. Recent diagnostic methodologies include imunocromatographic assays and molecular biology techniques. The use of the latter has improved enormously the sensitivity and specificity of TV diagnosis, despite, however, none being unable to identify the presence of live parasites. By understanding the biology, the pathogenesis, the proteomic profile and its relation with the parasite’s virulence mechanisms, new possibilities towards diagnostic techniques can arise. This review covers various important aspects of vaginal trichomonosis from the parasite’s biology and virulence to recent improvements in diagnostic techniques and also metabolic and protein discoveries. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Parasitologica Springer Journals

Trichomonas vaginalis: An Updated Overview Towards Diagnostic Improvement

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Publisher
Springer Journals
Copyright
Copyright © 2016 by Witold Stefański Institute of Parasitology, Polish Academy of Sciences
Subject
Biomedicine; Parasitology; Microbiology; Animal Systematics/Taxonomy/Biogeography; Ecology; Medical Microbiology
ISSN
1230-2821
eISSN
1896-1851
DOI
10.1515/ap-2016-0002
pmid
26751868
Publisher site
See Article on Publisher Site

Abstract

The protozoan Trichomonas vaginalis (TV) is responsible for trichomonosis, a sexually transmitted disease (STD) with a significant incidence worldwide. This infection is one of the most common non-viral STDs, representing almost 50% of all curable STDs. Trichomonosis has an incidence of 180 million new cases worldwide. Nowadays, the ‘gold standard’ for TV diagnosis remains the use of in vitro cultures combined with daily visual microscopic evaluations, which is a time-consuming and low sensitive method. Recent diagnostic methodologies include imunocromatographic assays and molecular biology techniques. The use of the latter has improved enormously the sensitivity and specificity of TV diagnosis, despite, however, none being unable to identify the presence of live parasites. By understanding the biology, the pathogenesis, the proteomic profile and its relation with the parasite’s virulence mechanisms, new possibilities towards diagnostic techniques can arise. This review covers various important aspects of vaginal trichomonosis from the parasite’s biology and virulence to recent improvements in diagnostic techniques and also metabolic and protein discoveries.

Journal

Acta ParasitologicaSpringer Journals

Published: Jan 1, 2016

References