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Trichuris suis secrete products that reduce disease severity in a multiple sclerosis model

Trichuris suis secrete products that reduce disease severity in a multiple sclerosis model Multiple sclerosis is a chronic inflammatory central nervous system (CNS) disease, which affects about 1 in 1000 individuals in the western world. It has been suggested that this relatively high prevalence is linked to a high level of hygiene, i.e. a reduced exposure to various microorganisms, including parasites. Parasites are known to employ different immunomodulatory and anti-inflammatory strategies, which enable them to evade destruction by the immune system. We have investigated the immunomodulation by the swine whipworm, Trichuris suis, by measuring the impact of oral administration of T. suis ova as well as of intraperitoneal administration of T. suis excretory/secretory products on the development and progression of experimental autoimmune encephalomyelitis — an animal model that shares clinical and pathological characteristics with multiple sclerosis. Intraperitoneal administration of excretory/secretory products before disease onset, resulted in a significant decrease in disease severity as well as markedly reduced TH1 and TH17 T-cell responses, centrally in the spinal cord as well as in the periphery, i.e. the spleen. Thus, parenteral administration of T. suis-derived products results in a skewing of the immune response with a significant impact on disease severity in a CNS inflammatory disease model. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Parasitologica Springer Journals

Trichuris suis secrete products that reduce disease severity in a multiple sclerosis model

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Publisher
Springer Journals
Copyright
Copyright © 2017 by Witold Stefański Institute of Parasitology, Polish Academy of Sciences
Subject
Biomedicine; Parasitology; Microbiology; Animal Systematics/Taxonomy/Biogeography; Ecology; Medical Microbiology
ISSN
1230-2821
eISSN
1896-1851
DOI
10.1515/ap-2017-0002
pmid
28030334
Publisher site
See Article on Publisher Site

Abstract

Multiple sclerosis is a chronic inflammatory central nervous system (CNS) disease, which affects about 1 in 1000 individuals in the western world. It has been suggested that this relatively high prevalence is linked to a high level of hygiene, i.e. a reduced exposure to various microorganisms, including parasites. Parasites are known to employ different immunomodulatory and anti-inflammatory strategies, which enable them to evade destruction by the immune system. We have investigated the immunomodulation by the swine whipworm, Trichuris suis, by measuring the impact of oral administration of T. suis ova as well as of intraperitoneal administration of T. suis excretory/secretory products on the development and progression of experimental autoimmune encephalomyelitis — an animal model that shares clinical and pathological characteristics with multiple sclerosis. Intraperitoneal administration of excretory/secretory products before disease onset, resulted in a significant decrease in disease severity as well as markedly reduced TH1 and TH17 T-cell responses, centrally in the spinal cord as well as in the periphery, i.e. the spleen. Thus, parenteral administration of T. suis-derived products results in a skewing of the immune response with a significant impact on disease severity in a CNS inflammatory disease model.

Journal

Acta Parasitologica – Springer Journals

Published: Jan 1, 2017

References

  • Studies on the biology of the life-cycle of Trichuris suis Schrank, 1788
    Beer, RJ
  • Multiple sclerosis
    Compston, A; Coles, A
  • The impact of parasite infections on the course of multiple sclerosis
    Correale, J; Farez, MF
  • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    Cua, DJ; Sherlock, J; Chen, Y; Murphy, CA; Joyce, B; Seymour, B
  • Multiple sclerosis and the hygiene hypothesis
    Fleming, JO; Cook, TD
  • Probiotic helminth administration in relapsing-remitting multiple sclerosis: a phase 1 study
    Fleming, JO; Isaak, A; Lee, J; Luzzio, C; Carrithers, M; Cook, TD
  • Trichinella spiralis: modulation of experimental autoimmune encephalomyelitis in DA rats
    Gruden-Movsesijan, A; Ilic, N; Mostarica-Stojkovic, M; Stosic-Grujicic, S; Milic, M; Sofronic-Milosavljevic, L
  • Mechanisms of modulation of experimental autoimmune en-cephalomyelitis by chronic Trichinella spiralis infection in Dark Agouti rats
    Gruden-Movsesijan, A; Ilic, N; Mostarica-Stojkovic, M; Stosic-Grujicic, S; Milic, M; Sofronic-Milosavljevic, L
  • Immunomodula-tory effects of helminths and protozoa in multiple sclerosis and experimental autoimmune encephalomyelitis
    Hasseldam, H; Ilic, N; Mostarica-Stojkovic, M; Stosic-Grujicic, S; Milic, M; Sofronic-Milosavljevic, L
  • Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
    Kebir, H; Kreymborg, K; Ifergan, I; Dodelet-Devillers, A; Cayrol, R; Bernard, M
  • Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis
    Kebir, H; Ifergan, I; Alvarez, JI; Bernard, M; Poirier, J; Arbour, N
  • Trichuris suis-induced modulation of human dendritic cell function is glycan-mediated
    Klaver, EJ; Kuijk, LM; Laan, L C; Kringel, H; Vliet, SJ; Bouma, G
  • Soluble helminth products suppress clinical signs in murine experimental autoimmune en-cephalomyelitis and differentially modulate human dendritic cell activation
    Kuijk, LM; Klaver, EJ; Kooij, G; Pol, SM; Heijnen, P; Bruijn, SC
  • Schistoso-miasis decreases central nervous system inflammation and alters the progression of experimental autoimmune en-cephalomyelitis
    Flamme, AC; Ruddenklau, K; Backstrom, BT
  • Excretory-secretory products of helminth parasites: effects on host immune responses
    Lightowlers, MW; Rickard, MD
  • Multiple sclerosis: geoepidemiology, genetics and the environment
    Milo, R; Kahana, E
  • Genetic models for CNS inflammation
    Owens, T; Wekerle, H; Antel, J
  • Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization
    Sewell, D; Qing, Z; Reinke, E; Elliot, D; Weinstock, J; Sandor, M; Fabry, Z
  • Hay fever, hygiene, and household size
    Strachan, DP
  • Trichuris suis therapy in Crohn’s disease
    Summers, RW; Elliott, DE; Urban, JF Jr; Thompson, R; Weinstock, JV
  • Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial
    Summers, RW; Elliott, DE; Urban, JF; Thompson, RA; Weinstock, J V
  • Trichuris suis ova therapy in relapsing multiple sclerosis is safe but without signals of beneficial effect
    Voldsgaard, A; Bager, P; Garde, E; Akeson, P; Leffers, AM; Madsen, CG
  • Infection with a helminth parasite attenuates autoimmunity through TGFbeta-mediated suppression of Th17 and Th1 responses
    Walsh, KP; Brady, MT; Finlay, CM; Boon, L; Mills, KH
  • Infection of non-encapsulated species of Trichinella ameliorates experimental autoimmune encephalomyelitis involving suppression of Th17 and Th1 response
    Wu, Z; Nagano, I; Asano, K; Takahashi, Y
  • Soluble egg antigen from Schistosoma japonicum modulates the progression of chronic progressive experimental autoimmune encephalomyelitis via Th2-shift response
    Zheng, X; Hu, X; Zhou, G; Lu, Z; Qiu, W; Bao, J; Dai, Y